Title: Expression of DR5 and DcR1 in human non-small cell lung cancer and its relationship with clinical significance and prognosis
Abstract: Objective To investigate the expression of tumor necrosis factor-related poptosis-inducing ligand(TRAIL) death receptor 5(DR5) and decoy receptor 1(DcR1) in human non-small cell lung cancer(NSCLC) and the relationship with clinical significance and prognosis.Methods Immunohistochemistry was used to detect the expression of DR5 and DcR1 in 45 cases of NSCLC and 42 cases of non-cancerous adjacent lung tissues and their clinical pathological parameters was analyzed.Results The expression rate of DR5 in NSCLC was 86.7%,and the high expression rate was 53.3%,while that in non-cancerous adjacent tissues was 76.2% and 11.9% respectively,showing statistic significance(P0.01).The expression rate of DcR1 in NSCLC was 28.9%,which was significantly lower in non-cancerous adjacent tissues(76.2%).The expression level of DR5 in NSCLC tissue was correlated with clinical stage,and the expression level of stage Ⅲ was significantly lower than that of stage Ⅰ and Ⅱ(P0.05),while the expression of DR5 and DcR1 in NSCLC tissue didn't relate to gender,age,the size of tumor and prognosis.Conclusion TRAIL receptors express in both NSCLC and non-cancerous adjacent lung tissues,but the difference of expression levels exists.The high expression level of DR5 might play an important role in TRAIL-induced apoptosis of NSCLC.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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