Title: Screening for Y chromosomal microdeletions in 810 patients with severe oligozoospermia and azoospermia
Abstract: Objective:Screening for Y chromosomal microdeletions in patients with primary azoospermia or severe oligospermia,to explore the clinical relationship between male infertility and of azoospermia factor(AZF) region deletion. Methods:Genome DNA of 810 patients(457 primary azoospermia and 353 severe oligospermia ) were screened by modified multiplex PCR. Results:Out of 810 patients,77 were found with Y chromosome microdeletion,with a rate of 9.5%,of which 31 were oligospermia with the deletion type of AZFc,46 were azoospermia with different deletion type. All the deletion type were: 3 (3.9%) cases in AZFa,2 (2.6%) cases in AZFb,63 (81.82%) cases in AZFc,4 (5.19%) cases in AZFb+c,5 (6.49%) cases in AZFa+b+c. Conclusions:Y chromosome microdeletion is one of the important reasons of primary azoospermia and oligospermia,most of the deletions happens in AZFc region,it is necessary to carry out regular screen for these patients,especially for oligospermia patients who plan to receive assisted reproduction technology.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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