Title: Genetic analysis of 343 cases with non-obstructive azoospermia or severe oligospermia.
Abstract:Objective
To explore the genetic causeof non-obstructive azoospermia or severe oligozoospermia in Jiaozuo area of Henan Province, and provide basisof clinical diagnosis and treatment.
Methods
R...Objective
To explore the genetic causeof non-obstructive azoospermia or severe oligozoospermia in Jiaozuo area of Henan Province, and provide basisof clinical diagnosis and treatment.
Methods
Routine karyotype analysisand the screening for Y chromosomal microdeletions in azoospermia factor (AZF) region were performed for 343 cases with azoospermia or severe oligozoospermia who were admitted to our hospital from January 2017 to December 2018.
Results
A total of 39 chromosomal abnormalities (11.37%) were detected in 343 patients, which including 27 cases (7.87%) of Klinefelter syndrome. A total of 44 cases (12.83%) of Y chromosome microdeletions were detected, which included 30 casesof AZFc deletion. Chromosome karyotype abnormalities and Y chromosome microdeletions were detected at the same timein 5 patients.
Conclusion
The incidence of chromosomal abnormalities and Y chromosome microdeletion was higher in patients with non-obstructive azoospermia or severe oligozoospermia. It was recommended to simultaneouslyperform karyotype analysis and screening for Y chromosomal microdeletions in azoospermia factor (AZF) region for them to provide high quality diagnosis and treatment.
Key words:
Azoospermia; Severe oligospermia; Karyotype analysis; Y chromosome microdeletionsRead More
Publication Year: 2019
Publication Date: 2019-08-15
Language: en
Type: article
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