Title: Effect of elevated serum uric acid and inflammatory reaction in the pathogenesis of coronary heart disease
Abstract: Objective To investigate the effect of elevated serum uric acid(UA) and inflammatory reaction in the pathogenesis of coronary heart disease(CHD).Methods Serum UA and high-sensitivity C-reactive protein(hsCRP) of patients with acute coronary syndrome(ACS group),stable angina pectoris(SAP group) and control(CO) groups were separately measured by chemical chromatometry and ELISA.Results The levels of serum UA and hsCRP were higher in ACS and SAP groups compared with CO group(P0.05),and the serum hsCRP level was higher in ACS group compared with SAP group(P0.05).The serum UA level was all positively correlated with hsCRP in SAP and ACS patients(r=0.662,0.802,P0.05).Moreover,in ACS and SAP groups,serum hsCRP levels were higher in patients with higher serum UA than the normal serum UA ones(P0.05).Conclusions The elevated serum UA is probably a risk factor of CHD and induces the pathogenesis and development of CHD by promoting the inflammatory reaction.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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