Title: Clinical Study of Shehuang Ganyan Mixture Combined with Adefovir Dipivoxil Tablets for Treatment of Chronic Hepatitis B
Abstract: Objective:To observe the therapeutic effect of Shehuang Ganyan Mixture combined with Adefovir Dipivoxil Tablets for the treatment of chronic hepatitis B.Methods:Patients met inclusion criteria were divided into two groups by randomized cards marked with numbers.Forty-nine cases in the treatment group were administrated with Adefovir Dipivoxil Tablets combined with Shehuang Ganyan Mixture,and forty-two cases in the control group were administrated with Adefovir Dipivoxil Tablets alone.The treatment course lasted 48 weeks.Traditional Chinese medical(TCM) symptoms before and after treatment were observed,and the changes of hepatic function,serum HBV-M and HBV DNA were monitored.Results:TCM symptom and signs scores of both groups were significantly increased(P 0.01 compared with those before treatment).After treatment,significant differences of TCM symptoms and signs scores were also found between the two groups(P 0.05 or P 0.01).Obvious improvement of hepatic function was found in both groups after treatment(P 0.05 compared with that before treatment),but the differences were insignificant between the two groups(P 0.05).The rate for HBeAb turning positive was 46.15% in the treatment group and was 26.47% in the control group,the difference being significant(P 0.05).There was no significant difference of the rate for HBeAg turning negative between the two groups(P 0.05).Conclusion:Shehuang Ganyan Mixture combined with Adefovir Dipivoxil Tablets has certain effect on chronic hepatitis B through improving the serum conversion rate of HBeAg and relieving TCM symptoms and signs.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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