Title: Effects of Adefovir Dipivoxil Combined with Fufang Biejia Ruangan Tablet on the Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B
Abstract: Objective: To investigate the clinical therapeutic effects of adefovir dipivoxil combined with Fufang Biejia Ruangan Pian on patients with hepatic fibrosis secondary to chronic viral hepatitis B.Method: 100 patients meeting the criteria were selected and randomly divided into observation group and control group,50 patients in each group;all the patients of both groups were given basic treatments,additionally,the control group was given adefovir dipivoxil capsules,while the observation group were given with Fufang Biejia Ruangan Pian and adefovir dipivoxil capsules,and the courses of treatment were 12 months.Result: The differences in the serum ALT,AST and TBIL levels when entering the group between the two groups were statistically insignificant(P0.05);after 12-month treatments,the serum ALT,AST and TBIL levels of both groups were decreased when compared with those before the treatments(P0.05),and the decreasing extents of the two groups were similar(P0.05).The differences in the serum hepatic fibrosis indexes(HA,PCⅢ,Ⅳ-C and LN) levels when entering the group between the two groups were statistically insignificant(P0.05);after 12-month treatments,the serum hepatic fibrosis indexes(HA,PCⅢ,Ⅳ-C and LN) levels of both groups were decreased when compared with those before the treatments(P0.05),but those of the observation group were decreased more significantly(P0.05).After 12-month treatments,the total effective rate of the observation group was 96.00%,was significantly higher than that of the control group(70.00%),and the difference was statistically significant(P0.05).Conclusion: Fufang Biejia Ruangan Pian combined with adefovir dipivoxil can effectively delay the progression of hepatic fibrosis in patients with chronic viral hepatitis B and elevate clinical therapeutic effects,and is worthy of clinical application.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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