Title: COMBINATION OF ROSIGLITAZONE AND INSULIN FOR TYPE 2 DIABETES MELLITUS
Abstract: Objective To assess the efficacy of rosiglitazone combined with insulin in treating patients with type 2 diabetes and its influence on body weight and insulin dosage. Methods Thirty-seven patients with poor outcome after treated with insulin alone were enrolled and administered with insulin plus rosiglitazone.HbA1c,fasting and postprandial blood glucose,changes in insulin dosage,body weight,blood pressure,liver and kidney function were determined after 12 and 24 weeks of the treatment.Results HbA1c,and blood glucose reduced obviously after treatment(t=3.54-5.63,P0.01),body weight increased in the end of 24 weeks,insulin dosage lowered(t=2.66,4.36;P0.05). Conclusion For those with poorly controlled type 2 diabetes treated with insulin alone can get a lasting improvement of blood sugar,reduction of insulin dose,and release of insulin resistance by giving rosiglitazone plus insulin.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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