Title: Effects of THP on the proliferation and apoptosis of nasopharyngeal carcinoma CNE2 cell
Abstract: Objective To evaluate the effects of tetrahydnopyrany adriamyrin(THP) on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC) CNE2 cell.Methods the NPC cell line CNE2 was cultured in vitro,and treated with different concentrations of THP.The cell proliferation was assayed with MTT test,and the expression of X-linked inhibitor ofapoptosis protein(XIAP) mRNA was detected by RT-PCR assay.Results The THP inhibited the proliferation of NPC cell and induced its apoptosis,which showed time and dose-effect relationship,the inhibitive effects increased with the increasing of action time and concentration of THP;the expression of XIAP mRNA reduced after exposure to THP.Conclusion THP can inhibit the proliferation of CNE2 cultured in vitro and induce apoptosis,which maybe related to the down-regulation of the XIAP expression.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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