Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2187963365', 'doi': None, 'title': '2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells.', 'display_name': '2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells.', 'publication_year': 2004, 'publication_date': '2004-11-01', 'ids': {'openalex': 'https://openalex.org/W2187963365', 'mag': '2187963365', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15525476'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15525476', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017234498', 'display_name': 'Ning Zhou', 'orcid': 'https://orcid.org/0000-0001-8771-8354'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ning Ning Zhou', 'raw_affiliation_strings': ['Sun-Yat-Sen University'], 'affiliations': [{'raw_affiliation_string': 'Sun-Yat-Sen University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101587495', 'display_name': 'Xiao‐Feng Zhu', 'orcid': 'https://orcid.org/0000-0002-1313-4783'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao Feng Zhu', 'raw_affiliation_strings': ['Experimental Research - State Key Laboratory of Oncology in South China'], 'affiliations': [{'raw_affiliation_string': 'Experimental Research - State Key Laboratory of Oncology in South China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001159397', 'display_name': 'Jun Zhou', 'orcid': 'https://orcid.org/0009-0003-7848-3612'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jun Ming Zhou', 'raw_affiliation_strings': ['Sun-Yat-Sen University'], 'affiliations': [{'raw_affiliation_string': 'Sun-Yat-Sen University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075443517', 'display_name': 'Man-Zhi Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Man Zhi Li', 'raw_affiliation_strings': ['Sun-Yat-Sen University'], 'affiliations': [{'raw_affiliation_string': 'Sun-Yat-Sen University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003672032', 'display_name': 'Xiao-Shi Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiao Shi Zhang', 'raw_affiliation_strings': ['Biotherapy Center'], 'affiliations': [{'raw_affiliation_string': 'Biotherapy Center', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100644445', 'display_name': 'Peng Huang', 'orcid': 'https://orcid.org/0000-0002-2152-9152'}, 'institutions': [{'id': 'https://openalex.org/I4210134225', 'display_name': 'Center for Translational Molecular Medicine', 'ror': 'https://ror.org/047wvvg23', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210134225']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Peng Huang', 'raw_affiliation_strings': ['Translational Molecular Pathology'], 'affiliations': [{'raw_affiliation_string': 'Translational Molecular Pathology', 'institution_ids': ['https://openalex.org/I4210134225']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105988342', 'display_name': 'Wen Qi Jiang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wen Qi Jiang', 'raw_affiliation_strings': ['Medical Oncology'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology', 'institution_ids': []}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3290, 'currency': 'EUR', 'value_usd': 3990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.38, 'has_fulltext': False, 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.622744, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '25', 'issue': '11', 'first_page': '1515', 'last_page': '20'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Role of Retinoic Acid in Biological Processes', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-?B Signaling in Inflammation and Cancer', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/2-methoxyestradiol', 'display_name': '2-Methoxyestradiol', 'score': 0.97804195}, {'id': 'https://openalex.org/keywords/fragmentation', 'display_name': 'Fragmentation (computing)', 'score': 0.5597143}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.49199912}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.460494}], 'concepts': [{'id': 'https://openalex.org/C2776260442', 'wikidata': 'https://www.wikidata.org/wiki/Q4596897', 'display_name': '2-Methoxyestradiol', 'level': 3, 'score': 0.97804195}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.84305716}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.7470249}, {'id': 'https://openalex.org/C2778997737', 'wikidata': 'https://www.wikidata.org/wiki/Q1693598', 'display_name': 'Nasopharyngeal carcinoma', 'level': 3, 'score': 0.7257498}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.65215766}, {'id': 'https://openalex.org/C43759708', 'wikidata': 'https://www.wikidata.org/wiki/Q3749256', 'display_name': 'DNA fragmentation', 'level': 4, 'score': 0.6166579}, {'id': 'https://openalex.org/C191015642', 'wikidata': 'https://www.wikidata.org/wiki/Q1132459', 'display_name': 'Fragmentation (computing)', 'level': 2, 'score': 0.5597143}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.49685887}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.49199912}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.47211254}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.4668551}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.45509762}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.4540823}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.43009126}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4287145}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.4247941}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37059438}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34633923}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29030114}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1906609}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1505318}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000077584', 'descriptor_name': '2-Methoxyestradiol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053938', 'descriptor_name': 'DNA Fragmentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053938', 'descriptor_name': 'DNA Fragmentation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15525476', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W100870282', 'https://openalex.org/W1502777806', 'https://openalex.org/W1582951342', 'https://openalex.org/W1876742335', 'https://openalex.org/W1932456362', 'https://openalex.org/W1970203467', 'https://openalex.org/W2012594231', 'https://openalex.org/W2012921202', 'https://openalex.org/W2056570618', 'https://openalex.org/W2073892547', 'https://openalex.org/W2115726636', 'https://openalex.org/W2134979684', 'https://openalex.org/W2163368660', 'https://openalex.org/W2357373185', 'https://openalex.org/W2465211919', 'https://openalex.org/W3035517351'], 'related_works': ['https://openalex.org/W2404021914', 'https://openalex.org/W2394065346', 'https://openalex.org/W2381733337', 'https://openalex.org/W2359459995', 'https://openalex.org/W2354858722', 'https://openalex.org/W2352689651', 'https://openalex.org/W2166435019', 'https://openalex.org/W2163368660', 'https://openalex.org/W2139149338', 'https://openalex.org/W2102073771', 'https://openalex.org/W2060747003', 'https://openalex.org/W2047817078', 'https://openalex.org/W2034426069', 'https://openalex.org/W2021797949', 'https://openalex.org/W2012921202', 'https://openalex.org/W2007896773', 'https://openalex.org/W1983964043', 'https://openalex.org/W1970203467', 'https://openalex.org/W1876742335', 'https://openalex.org/W1557630738'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2187963365', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-11T14:23:54.233482', 'created_date': '2016-06-24'}