Title: Evaluation of the Down-regulation effects with one-fourth-dose and with a half-dose depot triptorelin in IVF-ET
Abstract: Objective:To evaluate the down-regulation effects of one-fourth-dose and a half-dose depot triptorelin in vitro fertilization-embryo transfer(IVF-ET).Methods:A total of 290 cycles used long protcol was divided into two groups by the number of base antral follicles(AFCs):group A(AFCs 15) and group B(AFCs≥15),the down-regulation effects of one-fourth-dose and a half-dose depot triptorelin were compared in group A and group B.Results:The days of ovarian stimulation had no difference;In groups with one-fourth-dose triptorelin,the total dose of gonadotrophin(Gn) used was less with significance in group A(P 0.05),on the day of hCG given,serum LH level was slightly higher without significance(P 0.05) and without spontaneous premature LH surge,serum E2 level was significantly higher(P 0.001),serum P level was higher and embryo plantation rate was less with significance in group A(P 0.05),ovarian hyperstimulation syndrome(OHSS) rate was higher with significance in group B(P 0.001).The numbers of retrieved and normaly fertilized oocytes and good quality embryos,clinical pregnancy rate and micarrage rate had no difference.Conclusion:The down-regulation effects of one-fourth-dose and a half-dose depot triptorelin may be equal to the convention dose in IVE-ET;using one-fourth-dose depot triptorelin can decrease the total dose of Gn in people with less AFCs( 15) ;using a half-dose depot triptorelin can suppress pituitary adequately,avoid serum E2 too high and eventually reduce the risk of OHSS in people with more AFCs(≥15),so down regulation with less dose GnRHa should be individual.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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