Title: Application of reduced gonadotropin releasing hormone agonist in controlled ovarian hyperstimulation
Abstract: Objective: To evaluate the effect of a single reduced gonadotropin releasing hormone agonist (GnRHa) 1.25 mg dose and the regular GnRHa 3.75 mg dose on pituitary down-regulation in women undergoing controlled ovarian hyperstimulation (COH). Methods: Patients underwent IVF-ET or ICSI were divided into two groups randomly: the control group with 98 cases received regular GnRHa 3.75 mg and the study group with 93 cases received GnRHa reduced dose 1.25 mg. They started treatment on menstrual cycle day 19~21. The blood levels of E 2, LH and FSH were checked at the next menstrual cycle day 2, and HMG and IVF-ET were administrated. The number of oocytes retrieved, oocytes fertilized, embryos transferred, embryos frozen, pregnancy rates, ampules of HMG and cost of the drugs were recorded. The comparison of means was performed using a two-sample unpaired t-test. Results: There were no statistically significant differences between the two groups in number of oocytes retrieved, oocytes fertilized, embryos transferred, embryos frozen, pregnancy rates and concentrations of E 2, LH and FSH. However, the cost of the drugs and ampules of HMG reduced significantly when compared with the regular dosage group. Conclusion: The reduced dose of GnRHa is still an effective and safe way in COH.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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