Title: Study on the possible role of synaptophysin in the pathophysiology of diabetic retinopathy
Abstract:Objective To explore the possible role of Synaptophysin(SYN)in the pathophysiology of diabetic retinopathy.Methods Streptozotocin(STZ)-induced diabetic rats and normal rats were employed to study the ...Objective To explore the possible role of Synaptophysin(SYN)in the pathophysiology of diabetic retinopathy.Methods Streptozotocin(STZ)-induced diabetic rats and normal rats were employed to study the alteration of the SYN in the retina of diabetics by immunohistochemistry.The weight,blood sugar and urine sugar were also measured before and after model induction in both groups.Results The data of weight,blood sugar and urine sugar indicated no significant difference between the two groups before animal model induction.Four weeks after the induction of diabetes,the differences between the control and the diabetic group in weight,blood sugar and urine sugar were distinct(IP/II/I0.01).When compared with the normal retina,a significant decrease of SYN expression was observed in the diabetic rats' retina(IP/I0.01).Conclusions Experimental evidence showed down-regulation of SYN expression in retina of streptozotocin-induced diabetic rats under hyperglycemia condition,and it might play a role in the pathophysiology of diabetic retinopathy.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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