Title: Effect of lead exposure during pregnancy on MDA,SOD and MT in the brain of newborn mice
Abstract: Objective To investigate the effect of lead exposure during pregnancy on the levels of malondialdehyde(MDA),superoxide dismutase(SOD)and metallothionein(MT)in the brain of newborn mice.Method The mice of C 57 from the day 0 to end of gestation were treated with lead acetate through gastric feeding.The newborn mice were killed at the first day after birth.The levels of MDA,the SOD activity and the content of MT in the newborn mice brain were determined.Result Lead exposure of pregnant mice might enhance the level of MDA and MT in the brain of newborn mice,but the SOD activity in the brain was decreased.The changes were also dose-dependent on lead(P0.01).Conclusion The brain developmental toxicity of lead is related to the increasing of MDA level and the decreasing of SOD activity in brain.In addition,lead can also induce the production of MT in the developing brain,that suggests that MT may play a certain role in the transportation,metabolism and detoxification of lead.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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