Title: Effect of lead exposure during pregnancy on oxidation stress in the liver and brain of mice offspring
Abstract: Objective To investigate the influence of lead exposure during pregnancy on the liver and brain development and oxidative stress in the offspring tissues. Methods The C 57 mice from the day 0 to the end of gestation were treated with lead acetate by gavage. The litter weights and liver, brain weights were quantified after the mice were born. The levels of MDA, GSH and the SOD activities in the newborn mice liver and brain tissues were determined. The content of blood lead of the pregnant mice was also determined. Results The liver, brain and average nest weights appeared to be reduced in the pregnant mice exposed to lead. With the increasing of lead exposure, the level of MDA and GSH in tissues elevated while the SOD activity decreased. The changes showed a dose-dependent correlation with the dosage of lead exposure. Conclusion There was the same mechanism of the influence of lead on the embryo of adult. The influence of lead on the developing liver and brain might be due to its disturbance to the homeostasis of oxidation and anti-oxidation system.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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