Title: Effects of FGF-23 overexpression on SOD and GSH-PX activity and MDA contents in mouse renal,hepatic and hippocampal tissues
Abstract: Objective: To investigate the effects of fibroblast growth factor(FGF)-23 overexpression on oxidant and antioxidant systems in mouse renal,hepatic and hippocampal tissues in order to elucidate the mechanism of aging caused by FGF-23 overexpression.Methods: The serum phosphate levels,superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) activity and malondialdehyde(MDA) contents were measured and analyzed by the comparison of eight-week-old transgenic mice overexpressing human FGF-23 to their age-matched wild-type littermates.Results: Compared with the wild-type littermates,serum phosphate level of FGF-23 transgenic mice was decreased significantly(P0.001);SOD and GSH-PX activity were reduced significantly(P0.001),MDA content was increased significantly(P0.001) in renal tissue;SOD and GSH-PX activity were decreased significantly(P0.05 or P0.01) while MDA content was increased significantly(P0.01) in hippocampal tissue.However,there were no significant differences in SOD and GSH-PX activity and MDA contents in hepatic tissues between these two groups(P0.05).Conclusion: FGF-23 overexpression can result in oxidant injury in renal and hippocampal tissues which may be contributed to the aging caused by FGF-23 overexpression.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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