Title: Comparative Study for Clinical Effect of Different Doses of Atorvastatin Combined with Butylphthalide on Acute Cerebral Infarction
Abstract:Objective To compare the clinical effect of different doses of atorvastatin combined with butylphthalide on acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction wer...Objective To compare the clinical effect of different doses of atorvastatin combined with butylphthalide on acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction were selected in the People's Hospital of Inner Monggol Autonomous Region from February 2014 to February 2015, and they were randomly divided into standard dose group and large dose group,each of 45 cases. Patients of both groups received butylphthalide injection,and patients of standard dose group received extra atorvastatin( 10 mg / d),while patients of large dose group received extra atorvastatin( 20 mg / d),both groups treated for 14 days. Clinical effect, CSS score, Barthel index score, blood lipids index( including TC, TG,HDL-C,LDL-C) and serum hs-CRP level before and after treatment were compared between the two groups. Results The clinical effect of large dose group was statistically significantly better than that of standard dose group( u = 3. 062,P = 0. 002).No statistically significant differences of CSS score or Barthel index score was found between the two groups before treatment( P 0. 05); after treatment,CSS score of large dose group was statistically significantly lower than that of standard dose group,while Barthel index score of large dose group was statistically significantly higher than that of standard dose group( P 0. 05). No statistically significant differences of serum level of TC, TG, HDL-C, LDL-C or hs-CRP was found between the two groups before treatment( P 0. 05); after treatment, serum levels of TC, TG, LDL-C and hs-CRP of large dose group were statistically significantly lower than those of standard dose group,while serum HDL-C level of large dose group was statistically significantly higher than that of standard dose group( P 0. 05). Conclusion Compared with standard dose of atorvastatin combined with butylphthalide,large dose of atorvastatin combined with butylphthalide has better clinical effect in treating acute cerebral infarction,can more effectively relieve the neurological function impairment and improve the quality of life.Read More
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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