Title: Clinical study on probucol combined with atorvastatin in treatment of acute cerebral infarction
Abstract:Objective To investigate the clinical effect of probucol combined with atorvastatin in treatment of acute cerebral infarction. Methods The patients with acute cerebral infarction(80 cases) of Beijing ...Objective To investigate the clinical effect of probucol combined with atorvastatin in treatment of acute cerebral infarction. Methods The patients with acute cerebral infarction(80 cases) of Beijing Friendship Hospital Affiliated to Capital Medical University from May 2011 to May 2013 were randomly divided into treatment and control groups, and each group had 40 cases. The patients in the control group were po administered with Atorvastatin Tablets on the basis of conventional treatment, one tablet/time, once daily. The patients in the treatment group were po administered with Probucol Tablets at the basis of the control group, 4 tablets/time, twice daily. The patients in two groups were treated for 6 months. The related biochemical indexes, blood lipid levels, area of carotid atherosclerotic plaque, and film thickness of the carotid artery intima in two groups before and after treatment were compared. Results After treatment, hypersensitive C reactive protein, ox-LDL, MMP-2, MMP-9, and NIHSS score in two groups were significantly reduced, while serum level of adiponectin increased, and the difference was statistically significant in the same group before and after treatment(P 0.05). After treatment, these indicators in the treatment group improved better than those of control group, and there were differences between the two groups(P 0.05). After treatment, TC, TG, and LDL-C in two groups were significantly reduced, while HDL-C increased, and the difference was statistically significant in the same group before and after treatment(P 0.05). After treatment, TC, TG, and LDL-C in treatment group were lower than those in the control group, and there were differences between the two groups(P 0.05). After treatment, the area of carotid atherosclerotic plaque and film thickness of the carotid artery intima in two groups were significantly reduced, and the difference was statistically significant in the same group before and after treatment(P 0.05). After treatment, the two indicators in the treatment group were lower than those in the control group, and there were differences between the two groups(P 0.05). Conclusion Probucol combined with atorvastatin has the good clinical effect in treatment of acute cerebral infarction, and can decrease blood lipid level, while can inhibit the development of atherosclerotic plaque, which is worth clinical promotion.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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