Title: Clinical significance and their relation of EGFR and C-erb B-2 expression in breast carcinoma
Abstract: Objective:To study the significance of epidermal growth factor receptor(EGFR/HER1) and C-erb B-2(HER2) gene protien overexpression in breast carcinoma.Methods:Thirty six cases of adenoma and 86 cases of breast cancer were detected by SP immunohistochemistry.The relation of their expression were analysed.Results:EGFR was correlated with C-erb B-2 in breast carcinoma(r=0.70).The positive rates of EGFR and C-erb B-2 were 56.98%(49/86) and 70.93(61/86)(P0.05).The expression rates of EGFR and C-erb B-2 in the group of lymphnode metastasis and group of invasive cancer were higher than nonlymphnode metastasis and noninivasive cancer(P0.01).Conclusion:The EGFR and C-erb B-2 have combined effect for occurrence of breast cancer and they are predictive factors for breast cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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