Title: Expression of cyclooxygenase-2 and vascular endothelial growth factor in cholangiocarcinoma
Abstract: Objective To investigate the expression and significance of cyclooxygenase-2(COX-2),vasular endothelial growth factor(VEGF) in extrahepatic cholangiocarcinoma.Methods COX-2 and VEGF were detected in 51 cases of extrahepatic cholangiocarcinoma and 6 normal bile ductal tissues by immuohistochemistry.Results The positive rates of COX-2 and VEGF in cholangiocarcinoma tissues were 74.51% and 82.35% respectively,which were significantly higher than those in normal bile ductal tissues(0% and 50.0% respectively)(P0.01).Expression of COX-2 was possitively correlated with that of VEGF(r=0.519,P0.01).Conclusion The expression of COX-2 and VEGF in cholangiocarcinoma was related with metastasis of cholangiocarcinoma.The coexpression of COX-2 and VEGF might play an important role in angiogenesis,which promotes the growth,invasion and(metastasis) of extrahepatic cholangiocarcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot