Title: [The role of cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of gastric cancer].
Abstract: It has been known that cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF)-C are closely related with the development of tumors. To investigate the expression of COX-2 and VEGF-C in gastric cancer and the correlation between them.Sixty-four paraffin-embedded gastric cancer samples and 22 flesh gastric cancer samples were tested with using immunohistochemistry method and the reverse transcription-polymerase chain reaction technology respectively.The mean expressive density of COX-2 and VEGF-C mRNA in gastric cancer were both significantly higher than those in non-cancerous gastric mucosa (1.363 +/- 0.351 vs 0.763 +/- 0.304, 0.972 +/- 0.331 vs 0.314 +/- 0.215, P < 0.001). The positive rates of COX-2 and VEGF-C in 64 gastric cancer samples were 72% and 64% respectively. Their expression in the groups of lymph-node metastasis were higher than that of the non-lymph-node metastasis groups respectively (P < 0.05). Moreover, there was a close correlation between COX-2 and VEGF-C expression levels (P < 0.05).There are high COX-2 and VEGF-C expression in gastric cancer. Gastric tumor tissues that produce VEGF-C may have a higher lymphatic invasion and metastatic potential. COX-2 may participate in VEGF-C lymphangiogenic pathway and the high expression of them may play an important role in the lymphatic proliferation and spread in gastric cancer.
Publication Year: 2004
Publication Date: 2004-11-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 4
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