Title: Expressions and clinical significance of CXCR4 and VEGF in human holangiocarcinoma
Abstract: Objective To explore the expressions of CXCR4 and VEGF proteins in cholangiocarcinoma and their relationship with clinical pathological features and the prognosis. Methods Expression of CXCR4 and VEGF proteins were detected by SP immunohistochemical technique in 35 cases of extrahepatic cholangiocarcinoma,10 nomal bile duct tissues. Results The positive rates of CXCR4 and VEGF proteins were 54%(19/35)and 77%(27/35)in extrahepatic cholangiocarcinoma, respectively. The expression of CXCR4 protein was significantly positively correlated with that of VEGF protein(P 0.05) in cholangiocarcinoma. In contrast, no expression of CXCR4 and VEGF proteins was detected in 10 cases of nomal bile duct. The expression of CXCR4 and VEGF was closely related to metastasis and palindromia, but was not related to sex or age of the patients, tumor size or tumor differentiation. Conclusions There is a significant positive correlation between high expressions of CXCR4 and VEGF proteins in cholangiocarcinoma. The high expressions of CXCR4 and VEGF proteins may be related to the metastasis and palindromia of extrahepatic cholangiocarcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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