Title: A comparative study between aripiprazole and risperidone in treatment of first -onset schizophrenia
Abstract: Objective: To compare the efficacy and safety of aripiprazole and risperidone in the treatment of first-onset schizophrenia.Methods: Thirty-four schizophrenic patients were treated with aripiprazole and other thirty-four patients treated with risperidone.The therapeutic response and adverse effects of these two drugs were evaluated with the PANSS and TESS before and after the treatment.Results:The total effective rate of aripiprazole was 94.1% and 67.6% of the patients improved remarked.The total effective rate of risperidone was 97.1% and 61.8.% of the patients improved remarked.The PANSS scores in both groups decreased significantly after treatment for eight weeks.The clinical efficacy and the incidences of adverse effect between two groups had not any significant difference.However,the score of negative symptoms in aripiprazole group was significantly lower than that in risperidone group after two-week treatment. Conclusions:The two drugs have better effects and less adverse effects to schizophrenia.Aripiprazole improves clinical symptoms of the illness more quickly than risperidone and it is superior to risperidone in relieving extrapyramidal symptoms and weight gain.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 6
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