Title: Microvessel Density and Expression of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of Lip
Abstract: Objective: The aim of present study is to determine the effects of angiogenesis in cervical lymph node metastasis and progression of squamous cell carcinomas(SCC)of lip, and the distribution and expression of vascular endothelial growth factor(VEGF)in SCC of lip. Methods: Paraffin sections from 42 patients of SCC of lip were stained using the CD34 monoclonal antibody by immunohistochemical S-P method to demonstrate blood vessels. Expression of VEGF was determined using an immunohistochemical S-P method, and the positive expression of VEGF was determined according to the percent of the neoplastic cells showing VEGF immunoreactivity and the degree of staining. Results: The MVD of SCCof lip was significantly higher than that of normal control tissue(p0.001), The rate(61.90%)of the VEGF positive patients in SCC of lip was significantly higher than that in normal control tissue(10.00%, p0.001).The MVD of the VEGF positive patients in SCC of lip was significantly higher than that of the VEGF negative patients(p0.05).The MVD of SCC of lip with lymph node metastasis was not significantly higher than that of tumors without lymph node metastasis(p0.05). The rate(80.00%)of the VEGF positive patients in SCC of lip with lymph node metastasis was not significantly higher than that of tumors without lymph node metastasis(56.25%, p0.25). Conclusions: It was concluded that there was a association between angiogenesis and tumor progression in lip The expression of VEGF was a close association with MVD in SCC of lip.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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