Title: The significance and expression of vascular endothelial growth factor in human esophageal squamous carcinoma
Abstract: Objective: To investigate the clinical significance and expression of vascular endothelial growth factor (VEGF) in human esophageal squamous carcinoma. Methods: Expression of VEGF and angiogenesis in 72 cases of human esophageal squamous carcinoma and 10 specimen of normal esophageal tissue were measured immunohistochemically. Anti-VEGF monoclonal antibody was used for VEGF expression ,and a monoclonal antibody directed against CD34 was used to measure the microvessel density (MVD) . Results: Positive staining for VEGF was obtained in 40 of the 72 cases (55.6%) ;The mean MVD of the study population (67.5±27.6) was significantly elevated compared with that of the controls (29.9±9.4 ). The MVD in high-grade VEGF tumors was higher than that in VEGF-negative and low-grade VEGF tumors. MVD significantly increased with increasing VEGF expression . The expression of VEGF and MVD in tumors with metastatic lymph nodes was markedly higher than that in tumors without metastatic lymph nodes . Conclusion : There is VEGF expression in human esophageal squamous carcinoma . VEGF expression is significantly associated with MVD . The expression of VEGF and MVD is associated with the presence of metastatic lymph nodes and it can be a predictor for the choice of preoperative neoadjuvant therapy or determine the extent of surgery.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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