Title: Relationship between CD8+ T lymphocyte subsets and disease progression of HIV infected patients.
Abstract:Objective To explore the relationship between CD8+T lymphocyte subsets and disease progression of HIV infected patients. Methods CD8+/CD28+T,CD8+/CD38+T,CD8+/CD95+T,CD8+/HLA-DR+T lymphocyte cells in t...Objective To explore the relationship between CD8+T lymphocyte subsets and disease progression of HIV infected patients. Methods CD8+/CD28+T,CD8+/CD38+T,CD8+/CD95+T,CD8+/HLA-DR+T lymphocyte cells in the peripheral blood of 25 periodⅡ,35 periodⅢ HIV/AIDS patients and 26 normal subjects were examined by flow cytometer and HIV-RNA were detected by RT-PCR. Results It showed that in periodⅡ,periodⅢ HIV/AIDS and normal subjects,the number of CD8+/CD38+T cells and CD8+/HLA-DR+T cells were significantly different (P0.01),which were positively correlated with common logarithm of HIV-RNA load (r=0.480,P0.01; r=0.455,P0.01); In periodⅡ,periodⅢ patients,CD8+/CD95+T cells were higher than those in the normal subjects significantly (P0.01); In periodⅡpatients and normal subjects,CD8+/CD28+T cells were higher than those in periodⅢ patients significantly (P0.01).Conclusion The number of CD8+/CD38+T and CD8+/HLA-DR+T lymphocyte cells are cellcorrelated with disease progression and inmune balance in HIV infection.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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