Title: Expression of Midkine mRNA in serum of patients with breast cancer and its clinical significance
Abstract: 0bjective:To detect the expression of Midkine(MK)mRNA in serum of patients with breast cancer and evaluate its significance.Methods:The expression of MKmRNA in 42 cases of breast cancer and 25 cases of benign breast diseases were detected in blood samples using reverse transcription polymerase chain reaction(RT-PCR).Results:Among the 42 cases of breast cancer,33 cases(78.57%)were MKmRNA positive,while only 2 positive cases in benign breast diseases(χ2=31.283,P0.001).There was significantly correlations between its expression and infiltration and lymph node metastasis(P0.05),but tumor size and differentiation degree were unrelated(P0.05).Conclusion:MKmRNA plays an important role in the tumorigenesis,progression,metastasis and infiltration of breast cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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