Title: An Experimental Study of radiofrequency ablation and ethanol injection on the Liver neoplasms
Abstract: Objective to evalute effects and side effects of radiofrequency ablation and ethanol injection on the rabbits bearing VX-2 hepatic tumor. Methods 30 rabbits with liver neoplasms were randomly divided into 3 groups. Radiofrequency ablation(RFA group); Ethanol injection( PEI group); Normal saline (NS group).MRI scan were performed to examine the tumor size before and 2 weeks after treatment. The average growth rate of tumors were calculated to evaluate the therapeutic effectiveness.The changes of hepatic and nephric functions were detected in preoperative and postoperative. The necrotic rate of tumors were compared after killing the rabbits,and then the pathological examinations were performed. Results The average growth and necrotic rate of tumors were significant difference among 3 groups(P0.05)and the latter was highest in RFA group, 98.43±2.76%. The changes of hepatic and nephric functions were most manifest in RFA group. Pathologically ,tumor necrosis was severe in RFA group and there were multinucleated giant cell reaction and granuloma formation.It was Light -moderate necrosis in PEI group. Steatosis and tumor thrombus found in PEI group. Bile ducts unspoiled in each group.Conclusion The therapeutic efficacy of RFA was better than PEI, but for hepatic and nephric dysfunction than PEI obviously.Clinically, the selection of appropriate interventional treatment must base in hepatic and nephric functions.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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