Title: Comparative experimental study of therapeutic effects of commonly used interventional methods on the liver neoplasms
Abstract: Objective To evaluate the effects and side effects of four commonly used interventional methods on the rabbits bearing VX2 hepatic tumor. Methods A total of 50 rabbits with liver neoplasms were randomly divided into 5 groups, i.e.epirubicin HCL and ultra-fluid lipiodol (EPI+LP group), percutaneous ethanol injection (PEI group), transarterial chemoembolization (TACE group),radiofrequency ablation (RFA group) and normal saline (NS group). MRI scan were performed to examine the tumor size before and two weeks after the treatments. The average growth rates of tumors were calculated to evaluate the therapeutic effectiveness. The changes of hepatic and nephric functions were observed preoperatively and postoperatively. The evaluations of necrotic rates of tumors were performed after the pathological examinations were performed. Results Besides EPI+LP group and TACE group, there was significant difference among the other groups of the average growth rates of tumors (P0.05). There was significant difference in the necrotic rates of tumors among five groups (P0.05), and the RFA group remained the highest ([98.43±2.76]%). The changes of hepatic and nephric functions were most manifest in RFA group and TACE group. Pathologically, tumor necrosis was severe in RFA group, and there were multinucleated giant cell reaction and granuloma formation, while there were light to moderate necrosis in the others. Steatosis and tumor thrombus were found in PEI group. Bile ducts unspoiled in each group. Conclusion The therapeutic efficacy of RFA is the best in these groups, and that of PEI is the worst, while EPI+LP’s is similar to TACE’s. Clinically, the selection of appropriate interventional treatment must base on hepatic and nephric functions.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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