Title: Effect of propacetamol combined with sufentanil for patient-controlled intravenous analgesia after gynecological laparoscopic operation
Abstract: Objective To observe the analgesic efficacy and safety of propacetamol combined with sufentanil for patient-controlled intravenous analgesia(PCIA) after gynecological laparoscopic operation.Methods Sixty ASA Ⅰ or Ⅱ patients undergoing gynecological laparoscopic operation were randomized into one the two groups: the sufentanil group(group S) and the propacetamol plus sufentanil group(group PS).The PCIA composition was as follows: the group S,2 μg/kg sufentanil in 100 ml saline;the group PS,8 g propacetamol and 1 μg/kg sufentanil in 100 ml saline;both groups had the loading dose 5 ml,the infusion rate 2 ml/h,bolus dose 0.5 ml,and lockout time 15 min.Visual analog score(VAS) of pain and Ramsay sedation score were measured at 4,8,12,24 and 48 h during the analgesia.The side effects were recorded.Results In the two groups,the analgesia scorings were all less than 2 at each time points but without significant difference between the two groups.The Ramsay scores in the group S were significantly higher than the group PS at 4、8 and 12 h(P0.05).The incidence of side effects was lower in the group PS than the comparison(P0.05).Conclusion Propacetamol combined with sufentanil produces effective analgesia in patients after gynecological laparoscopic operation with less side effects.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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