Title: Protein expression of Livin in breast cancer and its correlations with prognosis
Abstract: 【Objective】 To investigate the expression of the apoptosis inhibitor Livin in breast cancer and its correlations with prognosis and to provide a theoretical basis for breast cancer diagnosis,clinical treatment and prognosis.【Methods】 The expressions of Livin was detected by immunohistochemistry Streptavidin-Peroxidase method in 20 cases of adjacent-carcinoma,10 cases of normal tissues and 50 cases of breast cancer;with clinical and pathological features and follow-up data,the Cox model analysis was established.【Results】 The positive expression of Livin was 58.0%(29/50) in the tissues from breast cancer,whereas its positive rate was 40%(8/20) in the corresponding adjacent breast tissues,and none of the 10 normal tissue showed Livin expression,with statistical significance(P 0.05);The expression of Livin in breast cancer was significantly related with clinical stage,histologic grade,auxiliary lymph node metastases and ER receptor status(P 0.05);The expression of Livin did not show correlation to age,tumor size,distant metastasis and her-2 status(P 0.05).3,5,10-year survival rates of patients with low expression of Livin were significantly higher than those of patients with high expression,statistically significant differences(P 0.05).Multivariate Cox regression analysis showed that clinical stage,histological grade,auxiliary lymph node metastasis,distant metastasis,and Her-2 were the independent risk factors affecting the survival rate of patients.【Conclusion】 The abnormal expression of Livin is closely related to the development and prognosis of breast cancer,which suggesting that Livin expression could be used as one of indicators to determine the progress and prognosis of breast cancer.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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