Title: Assessment of diastolic function in patients with hypertension by left ventricular flow propagation velocity and brain natriuretic peptide
Abstract: Objective:To evaluate the left ventricular diastolic function in patients with essential hypertension by the propagation velocity(Vp) of early flow into the left ventricular and the levels of brain natriuretic peptide(BNP).Methods:19 patients with essential hypertension and 20 healthy control were enrolled into the study.Vp was measured by color M-mode Doppler echocardiography.The levels of BNP were measured by ELISA.The peak flow velocity velocity E,A of mitral inflow by Doppller flow imaging were detected.The correlation between these Doppler parameters and BNP were analysed.Results:E,E/A and Vp in patients with hypertension were lower than those in control group(P 0.05),whereas A and BNP were increased(P 0.05).The serum concentration of BNP were negatively correlated with Vp in the patients with hypertension(r =-0.748,P 0.05).E/A were not correlated with Vp and BNP(r =-0.185 and-0.048,all P 0.05).Conclusion:Vp and BNP can reflect the changes of diastolic function in patients with hypertension.It may provide a good way to non-invasively evaluate the asymptomatic left ventricular diastolic dysfunction in patients with hypertension.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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