Title: Relationship of plasma B-type natriuretic peptide levels to echocardiographic diastolic indexes and mitral regurgitation in patients with systolic heart failure
Abstract: Objective : This study was designed to characterize the relationship of plasma B-type natri uretie peptide ( BNP) levels to echocardiographic diastolic indexes and mitral regurgitation (MR) in patients with systolic heart failure. Methods:In 62 patients with symptomatic SHF [left ventricular ejection fraction (LVEF) 0. 40] , we measured plasma BNP levels and performed comprehensive echocar-diography with assessment of left ventricular diastolic function, including transmitral diastolic flow and pulmonary venous flow. Results: Median plasma BNP levels increased with greater severity of diastolic dysfunction, as well as severity of mitral regurgitation . We found significant correlations (P0.01 for all) between BNP and indexes of diastolic function [early deceleration time(DT) ,r = -0. 37; systolic flow of pulmonary venous (S) , r = - 0. 47 ; diastolic flow of pulmonary venous ( D ) , r = 0. 38 ; D/S ratio, r=0.61 ]. Conclusion :Plasma BNP levels are significantly related to diastolic indexes measured from transmitral diastolic flow and pulmonary venous flow. Heterogeneity of BNP levels in patients with SHF reflects the severity of diastolic abnormality, and MR in addition to LVEF. These findings may explain the powerful relationship of BNP to symptoms and prognosis in SHF.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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