Title: THE EXPRESSION AND CLINIC SIGNIFICANCE OF EZH2 PROTEIN IN BREAST CANCER
Abstract: Objective This study is to explore the expression and clinic significance of EZH2(enhancer of zeste homolog2) protein in breast cancer.Methods The expressions of EZH2 protein in 40breast cancer with lymph node metastasis tissues,63breast cancer without lymph node metastasis tissues,31hyperplasia of mammary glands tissues by SP immunohistochemical method.Results The rate of expressions of EZH2 protein in 40breast cancer with lymph node metastasis tissues,63breast cancer without lymph node metastasis tissues,31hyperplasia of mammary glands tissues were 75.00%(30 /40),52.38%(33 /63),22.58%(7 /31) respectively.The expressions of EZH2 protein in cancer tissions was higher than that in hyperplasia of mammary glands tissues(p 0.01).Conclusion The abnormal expressions of EZH2 are closely associated with the development of breast cancer,which may play an important role in the development of breast cancer.The overexpressions of EZH2 is correlated to breast cancer progression and poor prognosis.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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