Title: Expression of P53 and Bcl-2 oncoproteins and its significance in laryngeal squamous cell carcinoma
Abstract: Objective:To investigate the clinicopathological significance of the expression of P53 and Bcl-2 oncoproteins in laryngeal squamous cell carcinoma(LSCC) Method: An immunohistochemical S-P method was used to examine the expression of P53 and Bcl-2 proteins in 20 samples of laryngeal normal mucosa (LNM), 38 samples laryngeal atypical hyperplasia (LAH) and 50 cases of LSCC Results: P53 oncoprotein was localized in the nuclei, Bcl-2 oncoprotein was mainly expressed in cytoplasm of cells In LNM,LAH and LSCC, the positive immunostaining rates of P53 protein were 0 0%(0/20)?52 6%(20/38)and 62 0%(31/50)respectively, there was statistical significance among three groups(χ 2=22 722 P=0 001 ); Bcl-2 protein, 5 0%(1/20)?76 3%(29/38)and 50 0% (25/50)respectively, there was statistical significance among three groups(χ 2=26 698 P=0 001) In G1,G2 and G3 LSCC, Bcl-2 positive expression were 11 1%(1/9)?44 0%(11/25)and 81 3%(13/16)respectively , there was statistical significance among three groups (χ 2=12 054 P=0 002) With the presence of lymph-node metastasis and without the presence of lymph-node metastasis, Bcl-2 immunoreactivity rates were 66 7%(18/27)and 30 4%(7/23) respectively, there was statistical significance between two groups(χ 2=6 522 P=0 011), while there was no statistical significance in the expression of P53(P0 05) In LAH and LSCC, an reverse relation was found between P53 and Bcl-2 expression(P0 05) Conclusion: The abnormal expression of p53 and Bcl-2 could be early molecular events in the carcinogenesis of larynx Over-expression of Bcl-2 is significantly associated with histological grading and lymph-node metastases The joint detection of P53 and Bcl-2 oncoprotein will be conducive to early diagnosis of LSCC and prognostic assessment of patients with LSCC [
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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