Title: Expression of P53,Bcl-2, and Bax in laryngeal squamous cell carcinoma tissue
Abstract: Aim: To investigate the clinical significance of P53,Bcl-2, and Bax expression in laryngeal carcinogenesis. Methods: Immunohistochemical method was used to detect the expression of P53,Bcl-2, and Bax in 20 samples of laryngeal normal mucosa (LNM), 38 samples of laryngeal atypical hyperplasia(LAH), and 50 cases of laryngeal squamous cell carcinoma(LSCC). Results: In LNM,LAH,and LSCC, the positive expression rates of P53 protein were 0(0/20),52.6%(20/38),and 62.0%(31/50),respectively,those of Bcl-2 protein were 5.0%(1/20),76.3%(29/38),and 50.0%(25/50),respectively, and those of Bax protein were 75.0%(15/20), 50.0%(19/38), and 64.0%(32/50).The expressions of P53 and Bcl-2 had significant differences among the 3 kinds of tissues(P0.01). Bcl-2 positive expression was associated with the pathological grading and lymph node metastasis(P0.01). In LSCC, a reverse relation was found between P53 and Bcl-2 expression (r s=-0.453,P0.01)and no relation was found between Bcl-2 and Bax expression or P53 and Bax expression. Conclusion: The abnomal expression of P53 and Bcl-2 can be early molecular events in the carcinogenesis of larynx. Over-expression of Bcl-2 is associated with histological grading and lymph node metastasis. The combined detection of P53 and Bcl-2 protein will be conductive to early diagnosis of LSCC and prognosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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