Title: ANTIINFLAMMATORY ACTIVITY OF TEPHROSIA PURPUREA LEAVES
Abstract: Summary The aim of the present study was to explore the probable antiinflammatory activity of different extracts of Tephrosia purpurea leaves using carrageenan induced inflammation in the rat. Male Wistar rats were treated orally with normal saline (as control group) and Tephrosia purpurea extracts (100, 200, 400, and 600 mg/kg), 60 min before 0.1 mL 1% carrageenan injection. Paw volume was measured before and 1, 2, and 3 h after the injection of carrageenan. The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA) followed by Dunnett’s test. The subplantar injection of carrageenan caused a time-dependent paw edema in the rat. Oral administration of Tephrosia purpurea extracts (100, 200, 400, and 600 mg/kg) inhibited paw swelling dose-dependently at 1, 2, and 3, h after carrageenan injection. We can conclude from the outcome of the present work that Tephrosia purpurea extracts exert an excellent antiinflammatory effect in rats.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 2
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