Title: STUDIES ON THE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF THE ETHANOLIC FRACTION OF THE ROOT EXTRACT OF TEPHROSIA PURPUREA (LINN) Research Article
Abstract: Tephrosia Purpurea has been widely used in the traditional medicinal system for the treatment of a variety of diseases. The effect of ethanolic extract of Tephrosia Purpurea was studied in different experimental animal models and it was revealed that the extract possesses significant analgesic and anti-inflammatory activities. Anti-inflammatory activity of ethanolic fraction of the root extract of Tephrosia purpurea was tested on carrageenan-induced hind paw oedema and cotton pellet granuloma models in Wistar albino rats. Diclofenac (25mg/kg p.o.) & Morphine (5 mg/kg p.o) were used as standard drugs for anti-inflammatory & analgesic activities. The paw diameter was measured at different time intervals and the dry granuloma weight was taken after the treatment. The paw diameter was measured at different time intervals and the dry granuloma weight was taken after the treatment. The evaluation of anti-inflammatory & analgesic activities were carried out using Carrageenan induced paw edema volume, Hot plate and Writhing response model which is comparable with standard drug Diclofenac (25mg/kg p.o.). The ethanolic fraction of the root extract of Tephrosia purpurea (400 mg/kg) showed the maximum inhibition (84.23%) of oedema at the end of 3hr following carrageenininduced rat paw oedema. In subacute inflammation, the extract showed (76.25%) reduction in granuloma weight. The TPEE at doses of (200 and 400 mg/kg) have shown promising effect in reducing the carrageenan induced paw edema volume in rats when compared with vehicle treated group. The TPEE at doses (200, 400 mg/kg) significantly reduced thermal and chemical induced nociception (Hot plate and writhing response) in mice when compared with vehicle treated group. The results prove that the the ethanolic fraction of the root extract of Tephrosia purpurea showed highest anti-inflammatory activity & analgesic activity in acute and subacute inflammation and also support the usage of traditional claims.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 2
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot