Title: Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals
Abstract: Aim : Present study evaluates the analgesic and anti-inflammatory activities of different fractions of Tephrosia purpurea using various experimental models. Materials and Methods: The analgesic activity of T. purpurea carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. The effects of the administration of reference standard (Ibuprofen and hydrocortisone) were also evaluated. Results: Five different fractions (TPI, TPII, TPIII, TPIV, and TPV) of T. purpurea at the dose level of 20 and 40 mg/kg, p.o. were tested. The fraction TPI (40 mg/kg, p.o.) and TPIII (40 mg/kg, p.o.) were found to be more effective in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation and acetic acid-induced writhing; however, TPI (20 mg/kg, p.o.) and TPIII (20 mg/kg, p.o.) were found to be more effective in increasing latency period in tail flick method. Conclusions: Out of five different fractions of T. purpurea tested, TPI and TPIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 6
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