Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2161298902', 'doi': 'https://doi.org/10.1128/cvi.05013-11', 'title': 'Clinical Significance of Interleukin-2/Gamma Interferon Ratios in Mycobacterium tuberculosis-Specific T-Cell Signatures', 'display_name': 'Clinical Significance of Interleukin-2/Gamma Interferon Ratios in Mycobacterium tuberculosis-Specific T-Cell Signatures', 'publication_year': 2011, 'publication_date': '2011-06-01', 'ids': {'openalex': 'https://openalex.org/W2161298902', 'doi': 'https://doi.org/10.1128/cvi.05013-11', 'mag': '2161298902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21632888', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3147354'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/cvi.05013-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114575275', 'display_name': 'Clinical and Vaccine Immunology', 'issn_l': '1556-679X', 'issn': ['1556-679X', '1556-6811'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3147354?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084264424', 'display_name': 'Franziska Suter‐Riniker', 'orcid': 'https://orcid.org/0000-0001-8568-578X'}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Franziska Suter-Riniker', 'raw_affiliation_strings': ['and University Hospital, Occupational Health Service, 2 Bern, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035578032', 'display_name': 'Antonia Berger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Antonia Berger', 'raw_affiliation_strings': ['and University Hospital, Occupational Health Service, 2 Bern, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047894888', 'display_name': 'Désirée Mayor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118564535', 'display_name': 'University of Bern', 'ror': 'https://ror.org/02k7v4d05', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I118564535']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Désirée Mayor', 'raw_affiliation_strings': ['1University of Bern, Institute for Infectious Diseases, Bern, Switzerland'], 'affiliations': [{'raw_affiliation_string': '1University of Bern, Institute for Infectious Diseases, Bern, Switzerland', 'institution_ids': ['https://openalex.org/I118564535']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003518187', 'display_name': 'Pascal Bittel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Pascal Bittel', 'raw_affiliation_strings': ['and University Hospital, Occupational Health Service, 2 Bern, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067955263', 'display_name': 'Patricia Iseli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118564535', 'display_name': 'University of Bern', 'ror': 'https://ror.org/02k7v4d05', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I118564535']}, {'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Patricia Iseli', 'raw_affiliation_strings': [' and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'University of Bern, Institute for Infectious Diseases,'], 'affiliations': [{'raw_affiliation_string': 'University of Bern, Institute for Infectious Diseases,', 'institution_ids': ['https://openalex.org/I118564535']}, {'raw_affiliation_string': ' and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001151283', 'display_name': 'Thomas Bodmer', 'orcid': 'https://orcid.org/0000-0002-4769-0796'}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Thomas Bodmer', 'raw_affiliation_strings': ['and University Hospital, Occupational Health Service, 2 Bern, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'and University Hospital, Occupational Health Service, 2 Bern, Switzerland', 'institution_ids': ['https://openalex.org/I2801112126']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5084264424'], 'corresponding_institution_ids': ['https://openalex.org/I2801112126'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.678, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.825522, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '18', 'issue': '8', 'first_page': '1395', 'last_page': '1396'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Diagnosis, Treatment, and Epidemiology of Nontuberculous Mycobacterial Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Genetic Basis of Primary Immunodeficiency Disorders', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quantiferon', 'display_name': 'QuantiFERON', 'score': 0.59869194}, {'id': 'https://openalex.org/keywords/mycobacterium-tuberculosis', 'display_name': 'Mycobacterium tuberculosis', 'score': 0.509791}, {'id': 'https://openalex.org/keywords/gamma-interferon', 'display_name': 'Gamma interferon', 'score': 0.496486}], 'concepts': [{'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.85655093}, {'id': 'https://openalex.org/C2780841837', 'wikidata': 'https://www.wikidata.org/wiki/Q24741149', 'display_name': 'Interferon gamma', 'level': 3, 'score': 0.68734926}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.6741994}, {'id': 'https://openalex.org/C2776763545', 'wikidata': 'https://www.wikidata.org/wiki/Q2893466', 'display_name': 'QuantiFERON', 'level': 5, 'score': 0.59869194}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5638058}, {'id': 'https://openalex.org/C3019837644', 'wikidata': 'https://www.wikidata.org/wiki/Q24741149', 'display_name': 'Gamma interferon', 'level': 4, 'score': 0.496486}, {'id': 'https://openalex.org/C2780277586', 'wikidata': 'https://www.wikidata.org/wiki/Q6046438', 'display_name': 'Interferon gamma release assay', 'level': 5, 'score': 0.45616916}, {'id': 'https://openalex.org/C191732599', 'wikidata': 'https://www.wikidata.org/wiki/Q14865947', 'display_name': 'Interleukin 4', 'level': 3, 'score': 0.44569117}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44314453}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.43041223}, {'id': 'https://openalex.org/C2780374374', 'wikidata': 'https://www.wikidata.org/wiki/Q194309', 'display_name': 'Mycobacterium', 'level': 3, 'score': 0.42001915}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.41647494}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.34883922}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.33373922}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32467604}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.31305522}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.21369395}, {'id': 'https://openalex.org/C2779806340', 'wikidata': 'https://www.wikidata.org/wiki/Q4254929', 'display_name': 'Latent tuberculosis', 'level': 4, 'score': 0.17716807}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.14289111}], 'mesh': [{'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D014376', 'descriptor_name': 'Tuberculosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014376', 'descriptor_name': 'Tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014376', 'descriptor_name': 'Tuberculosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/cvi.05013-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114575275', 'display_name': 'Clinical and Vaccine Immunology', 'issn_l': '1556-679X', 'issn': ['1556-679X', '1556-6811'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3147354', 'pdf_url': 'https://europepmc.org/articles/pmc3147354?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147354', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21632888', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3147354', 'pdf_url': 'https://europepmc.org/articles/pmc3147354?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1901355048', 'https://openalex.org/W1985860622', 'https://openalex.org/W1994938942', 'https://openalex.org/W2027946970', 'https://openalex.org/W2041554851', 'https://openalex.org/W2048019396', 'https://openalex.org/W2080190378', 'https://openalex.org/W2113853582', 'https://openalex.org/W2147180609', 'https://openalex.org/W2416521742', 'https://openalex.org/W3203490972', 'https://openalex.org/W4233943697'], 'related_works': ['https://openalex.org/W3174041660', 'https://openalex.org/W2912979170', 'https://openalex.org/W2756273630', 'https://openalex.org/W2356066588', 'https://openalex.org/W2355140839', 'https://openalex.org/W2161298902', 'https://openalex.org/W2154237346', 'https://openalex.org/W2078724808', 'https://openalex.org/W1978063739', 'https://openalex.org/W1965636774'], 'abstract_inverted_index': {'The': [0], 'simultaneous': [1], 'determination': [2], 'of': [3, 18, 27, 47], 'interleukin-2': [4], '(IL-2)': [5], 'and': [6], 'gamma': [7], 'interferon': [8], '(IFN-γ)': [9], 'in': [10, 20], 'QuantiFERON-TB': [11], 'test': [12], 'plasma': [13], 'supernatants': [14], 'permitted': [15], 'the': [16, 28, 44], 'detection': [17], 'shifts': [19], 'Mycobacterium': [21], 'tuberculosis-specific': [22], 'T-cell': [23], 'signatures.': [24], 'A': [25], 'subset': [26], '84': [29], 'subjects': [30], 'tested': [31], 'revealed': [32], 'a': [33, 41], 'significantly': [34], 'elevated': [35], 'IL-2/IFN-γ': [36], 'ratio,': [37], 'which': [38], 'may': [39], 'be': [40], 'marker': [42], 'for': [43], 'successful': [45], 'elimination': [46], 'M.': [48], 'tuberculosis': [49], 'infection.': [50]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161298902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T13:34:57.115014', 'created_date': '2016-06-24'}