Title: Diagnostic value of interferon-gamma release assay T-SPOT.TB for tuberculosis
Abstract: Objective To evaluate the diagnostic value of an interferon-gamma release assay T-SPOT.TB in tuberculosis.Methods T-SPOT.TB assay reagent was employed to detect Mycobacterium tuberculosis antigen specific T cells in the peripheral blood samples from the patients with suspected tuberculosis.Results The positive detection rate was 83.3%(20/24) by interferon-gamma release assay T-SPOT.TB was significantly higher than 41.7%(10/24) by tuberculin test,26.7%(4/15) in smear for acid-fast bacillus and 22.2%(2/9) in mycobacteria separation culture with statistical differences(P0.05).The sensitivity and specificity of interferon-gamma release assay T-SPOT.TB were 83.3% and 96.4%,which were significantly higher than those of tuberculin test with statistical differences(P0.05).Conclusions Interferon-gamma release assay T-SPOT.TB is rapid and high-sensitive test for diagnosing tuberculosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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