Publication Information

{'id': 'https://openalex.org/W2142868310', 'doi': 'https://doi.org/10.18632/oncotarget.1431', 'title': 'Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells', 'display_name': 'Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells', 'publication_year': 2013, 'publication_date': '2013-11-24', 'ids': {'openalex': 'https://openalex.org/W2142868310', 'doi': 'https://doi.org/10.18632/oncotarget.1431', 'mag': '2142868310', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24280348', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3926838'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1431', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1431&path%5B%5D=1751', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1431&path%5B%5D=1751', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102832372', 'display_name': 'Kai Wu', 'orcid': 'https://orcid.org/0000-0003-4835-8741'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kai Wu', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103481305', 'display_name': 'Qingshan Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qingshan Chang', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109266194', 'display_name': 'Yongju Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yongju Lu', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007646350', 'display_name': 'Ping Qiu', 'orcid': 'https://orcid.org/0000-0003-4090-5704'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ping Qiu', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087429893', 'display_name': 'Bailing Chen', 'orcid': 'https://orcid.org/0000-0003-0065-4613'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bailing Chen', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071569717', 'display_name': 'Chitra Thakur', 'orcid': 'https://orcid.org/0000-0002-4356-2543'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chitra Thakur', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080367728', 'display_name': 'Jiaying Sun', 'orcid': 'https://orcid.org/0000-0003-2211-9937'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiaying Sun', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100718441', 'display_name': 'Lingzhi Li', 'orcid': 'https://orcid.org/0000-0002-6185-3467'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lingzhi Li', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081710987', 'display_name': 'Anjaneyulu Kowluru', 'orcid': 'https://orcid.org/0000-0003-1700-0077'}, 'institutions': [{'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anjaneyulu Kowluru', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I12311892', 'https://openalex.org/I185443292']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100405374', 'display_name': 'Fei Chen', 'orcid': 'https://orcid.org/0000-0002-1679-9932'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}, {'id': 'https://openalex.org/I12311892', 'display_name': 'Eugene Applebaum College of Pharmacy and Health Sciences', 'ror': 'https://ror.org/0222p1e69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12311892']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fei Chen', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I185443292', 'https://openalex.org/I12311892']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.14, 'has_fulltext': False, 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.852485, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '4', 'issue': '12', 'first_page': '2430', 'last_page': '2438'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.95944935}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.71880454}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6909054}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.6075615}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.5991386}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5121567}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.47442785}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.4717204}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.46900555}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38376287}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3372236}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3354478}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29672173}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.20602691}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17687508}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.10759157}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.07628593}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1431', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1431&path%5B%5D=1751', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3926838', 'pdf_url': 'https://europepmc.org/articles/pmc3926838?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24280348', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1431', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1431&path%5B%5D=1751', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1879729745', 'https://openalex.org/W1944006395', 'https://openalex.org/W1967249248', 'https://openalex.org/W1974213646', 'https://openalex.org/W1980696888', 'https://openalex.org/W1988719795', 'https://openalex.org/W1998058516', 'https://openalex.org/W1998727693', 'https://openalex.org/W1998971866', 'https://openalex.org/W1999503941', 'https://openalex.org/W2002331964', 'https://openalex.org/W2003681585', 'https://openalex.org/W2015613195', 'https://openalex.org/W2016710415', 'https://openalex.org/W2018322688', 'https://openalex.org/W2019768326', 'https://openalex.org/W2021312892', 'https://openalex.org/W2023806468', 'https://openalex.org/W2024282024', 'https://openalex.org/W2043911313', 'https://openalex.org/W2044227662', 'https://openalex.org/W2052137378', 'https://openalex.org/W2062114901', 'https://openalex.org/W2066567180', 'https://openalex.org/W2074356752', 'https://openalex.org/W2091541206', 'https://openalex.org/W2094808636', 'https://openalex.org/W2096540669', 'https://openalex.org/W2100429833', 'https://openalex.org/W2105437003', 'https://openalex.org/W2107038478', 'https://openalex.org/W2110218677', 'https://openalex.org/W2115009923', 'https://openalex.org/W2117222458', 'https://openalex.org/W2138536086', 'https://openalex.org/W2153156618', 'https://openalex.org/W2169363183', 'https://openalex.org/W2169460814', 'https://openalex.org/W2236524872', 'https://openalex.org/W41965769', 'https://openalex.org/W4239536744', 'https://openalex.org/W4243504014'], 'related_works': ['https://openalex.org/W3147989365', 'https://openalex.org/W2418692205', 'https://openalex.org/W2408927976', 'https://openalex.org/W2363852307', 'https://openalex.org/W2348666640', 'https://openalex.org/W2280113021', 'https://openalex.org/W2254126652', 'https://openalex.org/W2184487997', 'https://openalex.org/W2168841302', 'https://openalex.org/W2015104488'], 'abstract_inverted_index': {'//': [0, 63], 'Kai': [1], 'Wu': [2], '1': [3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 40], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36], 'Qingshan': [5], 'Chang': [6], 'Yongju': [9], 'Lu': [10], 'Ping': [13], 'Qiu': [14], 'Bailing': [17], 'Chen': [18, 38], 'Chitra': [21], 'Thakur': [22], 'Jiaying': [25], 'Sun': [26], 'Lingzhi': [29], 'Li': [30], 'Anjaneyulu': [33], 'Kowluru': [34], 'Fei': [37, 60], 'Department': [41], 'of': [42, 48, 88, 128, 145, 151, 163, 168, 179, 194, 205, 211, 230], 'Pharmaceutical': [43], 'Sciences,': [44, 52], 'Eugene': [45], 'Applebaum': [46], 'College': [47], 'Pharmacy': [49], 'and': [50, 102, 113, 184, 224], 'Health': [51], 'Wayne': [53], 'State': [54], 'University,': [55], 'Detroit,': [56], 'MI,': [57], 'USA': [58], 'Correspondence:': [59], 'Chen,': [61], 'email:': [62], 'Keywords': [64], ':': [65, 72, 77, 82], 'Gefitinib,': [66], 'EGFR,': [67], 'STAT3,': [68, 154], 'Akt': [69, 139, 173, 182], 'recovery': [70], 'Received': [71], 'September': [73], '22,': [74, 79], '2013': [75, 80, 85], 'Accepted': [76], 'November': [78, 83], 'Published': [81], '24,': [84], 'Abstract': [86], 'Hyperactivation': [87], 'Epidermal': [89], 'Growth': [90], 'Factor': [91], 'Receptor': [92], '(EGFR)': [93], 'tyrosine': [94, 107], 'kinase': [95, 108], 'is': [96, 207], 'prevalent': [97], 'in': [98, 170, 214, 236], 'human': [99], 'lung': [100, 237], 'cancer': [101], 'its': [103], 'inhibition': [104, 178, 189], 'by': [105], 'the': [106, 126, 143, 192, 195, 228], 'inhibitors': [109], '(TKIs),': [110], 'including': [111], 'gefitinib': [112, 148, 186, 231], 'erlotinib,': [114], 'initially': [115], 'controls': [116], 'tumor': [117, 196], 'growth.': [118], 'However,': [119], 'most': [120], 'patients': [121], 'ultimately': [122], 'relapse': [123], 'due': [124], 'to': [125, 216], 'development': [127], 'drug': [129, 212], 'resistance.': [130], 'In': [131], 'this': [132, 200], 'study,': [133], 'we': [134], 'have': [135], 'discovered': [136], 'a': [137, 166], 'STAT3-dependent': [138], 'activation': [140, 183, 204], 'that': [141, 203], 'impairs': [142], 'efficacy': [144, 229], 'gefitinib.': [146], 'Mechanistically,': [147], 'increased': [149], 'association': [150], 'EGFR': [152, 217, 223, 234], 'with': [153, 187], 'which': [155], 'de-repressed': [156], 'STAT3': [157, 169, 180, 188, 206, 225], 'from': [158], 'SOCS3,': [159], 'an': [160, 208], 'upstream': [161], 'suppressor': [162], 'STAT3.': [164], 'Such': [165], 'de-repression': [167], 'turn': [171], 'fostered': [172], 'activation.': [174], 'Genetic': [175], 'or': [176, 232], 'pharmacological': [177], 'abrogated': [181], 'combined': [185], 'synergistically': [190], 'reduced': [191], 'growth': [193], 'cells.': [197], 'Taken': [198], 'together,': [199], 'study': [201], 'suggests': [202], 'intrinsic': [209], 'mechanism': [210], 'resistance': [213], 'response': [215], 'TKIs.': [218], 'Combinational': [219], 'targeting': [220], 'on': [221], 'both': [222], 'may': [226], 'enhance': [227], 'other': [233], 'TKIs': [235], 'cancer.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142868310', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 6}], 'updated_date': '2024-12-12T09:42:51.280731', 'created_date': '2016-06-24'}