Title: Comparison of the efficacy of gefitinib and erlotinib as a second line treatment for advanced non-small cell lung cancer
Abstract:Objective To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and erlotinib alone as a second line treatment for patients with advanced non-small...Objective To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and erlotinib alone as a second line treatment for patients with advanced non-small cell lung cancer(NSCLC) who were failed in the first-line chemotherapy.Methods Among the 83 patients who were failed in the first-line treatment for NSCLC,41 received gefitinib(gefitinib group) and 42 received erlotinib(erlotinib) therapy.The efficacy,progression-free survival time(PFS),median survival time(MST),and toxicity of the two groups were compared.Results The median PFS and median OS were not significantly different between the two groups(P 0.05).The rate of adverse events in erlotinib group was higher than that in gefitinib group.The histological types of tumor were significantly different between the two groups(P 0.05),and the survival time in patients with squamous carcinoma in erlotinib group was longer than that in gefitinib group.Conclusion In the advanced NSCLC patients with standard first-line chemotherapy treatment failure,gefitinib and erlotinib had the similar overall efficacy.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 2
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