Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2168841302', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-06-0462', 'title': 'Exon 19 Deletion Mutations of Epidermal Growth Factor Receptor Are Associated with Prolonged Survival in Non–Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib', 'display_name': 'Exon 19 Deletion Mutations of Epidermal Growth Factor Receptor Are Associated with Prolonged Survival in Non–Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib', 'publication_year': 2006, 'publication_date': '2006-07-01', 'ids': {'openalex': 'https://openalex.org/W2168841302', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-06-0462', 'mag': '2168841302', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16818686'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-06-0462', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104110519', 'display_name': 'David M. Jackman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'David M. Jackman', 'raw_affiliation_strings': ['1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', '3Medicine and'], 'affiliations': [{'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', 'institution_ids': ['https://openalex.org/I4210102457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114045816', 'display_name': 'Beow Y. Yeap', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Beow Y. Yeap', 'raw_affiliation_strings': ['3Medicine and', '5Medicine and'], 'affiliations': [{'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '5Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075333926', 'display_name': 'Lecia V. Sequist', 'orcid': 'https://orcid.org/0000-0002-8965-6991'}, 'institutions': [{'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Lecia V. Sequist', 'raw_affiliation_strings': ['3Medicine and', '5Medicine and', '7Massachusetts General Hospital Cancer Center; Departments of'], 'affiliations': [{'raw_affiliation_string': '5Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '7Massachusetts General Hospital Cancer Center; Departments of', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035004148', 'display_name': 'Neal I. Lindeman', 'orcid': 'https://orcid.org/0000-0002-7092-6859'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Neal Lindeman', 'raw_affiliation_strings': ['8Pathology and'], 'affiliations': [{'raw_affiliation_string': '8Pathology and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110476030', 'display_name': 'Alison J. Holmes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alison J. Holmes', 'raw_affiliation_strings': ['1Lowe Center of Thoracic Oncology, Department of Medical Oncology and'], 'affiliations': [{'raw_affiliation_string': '1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', 'institution_ids': ['https://openalex.org/I4210102457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071618684', 'display_name': 'Victoria A. Joshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210105714', 'display_name': 'Center for Human Genetics', 'ror': 'https://ror.org/01gcrbc43', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105714']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Victoria A. Joshi', 'raw_affiliation_strings': ['11Laboratory for Molecular Medicine, Harvard-Partners Center for Genetics and Genomics, Cambridge, Massachusetts; and', '6Pathology, Massachusetts General Hospital;'], 'affiliations': [{'raw_affiliation_string': '6Pathology, Massachusetts General Hospital;', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': '11Laboratory for Molecular Medicine, Harvard-Partners Center for Genetics and Genomics, Cambridge, Massachusetts; and', 'institution_ids': ['https://openalex.org/I4210105714']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046992202', 'display_name': 'Daphne W. Bell', 'orcid': 'https://orcid.org/0000-0001-7314-3932'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daphne W. Bell', 'raw_affiliation_strings': ['6Pathology, Massachusetts General Hospital;', '7Massachusetts General Hospital Cancer Center; Departments of'], 'affiliations': [{'raw_affiliation_string': '7Massachusetts General Hospital Cancer Center; Departments of', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': '6Pathology, Massachusetts General Hospital;', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057898983', 'display_name': 'Mark S. Huberman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark S. Huberman', 'raw_affiliation_strings': ['10Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts;'], 'affiliations': [{'raw_affiliation_string': '10Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts;', 'institution_ids': ['https://openalex.org/I1316535847']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081356537', 'display_name': 'Balázs Halmos', 'orcid': 'https://orcid.org/0000-0001-7548-8360'}, 'institutions': [{'id': 'https://openalex.org/I2799343972', 'display_name': 'University Hospitals of Cleveland', 'ror': 'https://ror.org/0130jk839', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799343972']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Balazs Halmos', 'raw_affiliation_strings': ['12Ireland Cancer Center, University Hospitals of Cleveland, Case School of Medicine, Cleveland, Ohio'], 'affiliations': [{'raw_affiliation_string': '12Ireland Cancer Center, University Hospitals of Cleveland, Case School of Medicine, Cleveland, Ohio', 'institution_ids': ['https://openalex.org/I2799343972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041342932', 'display_name': 'Michael S. Rabin', 'orcid': 'https://orcid.org/0000-0003-2491-5451'}, 'institutions': [{'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Michael S. Rabin', 'raw_affiliation_strings': ['1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', '3Medicine and', "9Medicine, Brigham and Women's Hospital;"], 'affiliations': [{'raw_affiliation_string': '1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', 'institution_ids': ['https://openalex.org/I4210102457']}, {'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': "9Medicine, Brigham and Women's Hospital;", 'institution_ids': ['https://openalex.org/I1283280774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038280749', 'display_name': 'Daniel A. Haber', 'orcid': 'https://orcid.org/0000-0003-1378-6551'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel A. Haber', 'raw_affiliation_strings': ['6Pathology, Massachusetts General Hospital;', '7Massachusetts General Hospital Cancer Center; Departments of'], 'affiliations': [{'raw_affiliation_string': '7Massachusetts General Hospital Cancer Center; Departments of', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': '6Pathology, Massachusetts General Hospital;', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003723404', 'display_name': 'Thomas J. Lynch', 'orcid': 'https://orcid.org/0000-0001-8789-7567'}, 'institutions': [{'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Thomas J. Lynch', 'raw_affiliation_strings': ['3Medicine and', '5Medicine and', '7Massachusetts General Hospital Cancer Center; Departments of'], 'affiliations': [{'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '5Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '7Massachusetts General Hospital Cancer Center; Departments of', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056373767', 'display_name': 'Matthew Meyerson', 'orcid': 'https://orcid.org/0000-0002-9133-8108'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Meyerson', 'raw_affiliation_strings': ['2Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of', '4Pathology, Harvard Medical School; Departments of'], 'affiliations': [{'raw_affiliation_string': '2Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': '4Pathology, Harvard Medical School; Departments of', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053521833', 'display_name': 'Bruce E. Johnson', 'orcid': 'https://orcid.org/0000-0002-5252-3677'}, 'institutions': [{'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Bruce E. Johnson', 'raw_affiliation_strings': ['1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', '3Medicine and', "9Medicine, Brigham and Women's Hospital;"], 'affiliations': [{'raw_affiliation_string': '1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', 'institution_ids': ['https://openalex.org/I4210102457']}, {'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': "9Medicine, Brigham and Women's Hospital;", 'institution_ids': ['https://openalex.org/I1283280774']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048675362', 'display_name': 'Pasi A. Jänne', 'orcid': 'https://orcid.org/0000-0002-7821-4928'}, 'institutions': [{'id': 'https://openalex.org/I4210145571', 'display_name': 'Immunovaccine (Canada)', 'ror': 'https://ror.org/05c2mc090', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210145571']}, {'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Pasi A. Jänne', 'raw_affiliation_strings': ['1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', '3Medicine and', "9Medicine, Brigham and Women's Hospital;"], 'affiliations': [{'raw_affiliation_string': '3Medicine and', 'institution_ids': ['https://openalex.org/I4210145571']}, {'raw_affiliation_string': '1Lowe Center of Thoracic Oncology, Department of Medical Oncology and', 'institution_ids': ['https://openalex.org/I4210102457']}, {'raw_affiliation_string': "9Medicine, Brigham and Women's Hospital;", 'institution_ids': ['https://openalex.org/I1283280774']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 35.405, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 568, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '12', 'issue': '13', 'first_page': '3908', 'last_page': '3914'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10696', 'display_name': 'Gastric Cancer Management and Outcomes', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/erlotinib-hydrochloride', 'display_name': 'Erlotinib Hydrochloride', 'score': 0.5294865}], 'concepts': [{'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.98520243}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.9689577}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.8402265}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.75520146}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6200841}, {'id': 'https://openalex.org/C36823959', 'wikidata': 'https://www.wikidata.org/wiki/Q373027', 'display_name': 'Exon', 'level': 3, 'score': 0.6117164}, {'id': 'https://openalex.org/C2909325608', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib Hydrochloride', 'level': 5, 'score': 0.5294865}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.51878595}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4971569}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.42938077}, {'id': 'https://openalex.org/C176944494', 'wikidata': 'https://www.wikidata.org/wiki/Q1415380', 'display_name': 'Point mutation', 'level': 4, 'score': 0.4220982}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3781682}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31242225}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26327282}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07916686}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07016802}], 'mesh': [{'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004273', 'descriptor_name': 'DNA, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004273', 'descriptor_name': 'DNA, Neoplasm', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069347', 'descriptor_name': 'Erlotinib Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-06-0462', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16818686', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.82, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W152953340', 'https://openalex.org/W1963592300', 'https://openalex.org/W1970476748', 'https://openalex.org/W1979300931', 'https://openalex.org/W1988442083', 'https://openalex.org/W1990485105', 'https://openalex.org/W2001783515', 'https://openalex.org/W2002937040', 'https://openalex.org/W2003984225', 'https://openalex.org/W2030662132', 'https://openalex.org/W2037139573', 'https://openalex.org/W2037873277', 'https://openalex.org/W2043696829', 'https://openalex.org/W2049484790', 'https://openalex.org/W2097331522', 'https://openalex.org/W2101778620', 'https://openalex.org/W2106297623', 'https://openalex.org/W2114642822', 'https://openalex.org/W2120718661', 'https://openalex.org/W2124214040', 'https://openalex.org/W2135595269', 'https://openalex.org/W2138297714', 'https://openalex.org/W2138312420', 'https://openalex.org/W2139236349', 'https://openalex.org/W2139248078', 'https://openalex.org/W2140775102', 'https://openalex.org/W2143171062', 'https://openalex.org/W2143859186', 'https://openalex.org/W2146404049', 'https://openalex.org/W2150501295', 'https://openalex.org/W2153477391', 'https://openalex.org/W2161821474', 'https://openalex.org/W2165119042', 'https://openalex.org/W2166351918', 'https://openalex.org/W2168554121', 'https://openalex.org/W2242356173', 'https://openalex.org/W3145077989', 'https://openalex.org/W3147894994', 'https://openalex.org/W4293241248'], 'related_works': ['https://openalex.org/W4362489402', 'https://openalex.org/W3147989365', 'https://openalex.org/W2575565717', 'https://openalex.org/W2557772662', 'https://openalex.org/W2254126652', 'https://openalex.org/W2168841302', 'https://openalex.org/W2154670277', 'https://openalex.org/W2154226624', 'https://openalex.org/W2142865455', 'https://openalex.org/W2088932689'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose:': [1], 'Somatic': [2], 'mutations': [3, 89, 284], 'in': [4, 14, 185, 191, 220], 'the': [5, 36, 39, 52, 104, 172, 257, 276], 'epidermal': [6], 'growth': [7], 'factor': [8], 'receptor': [9], '(EGFR)': [10], 'have': [11, 243], 'been': [12], 'detected': [13], 'patients': [15, 59, 111, 139, 173, 195, 265], 'with': [16, 25, 29, 62, 73, 83, 112, 121, 126, 138, 140, 174, 197, 200, 236, 249, 254, 256, 285, 289], 'non–small': [17], 'cell': [18], 'lung': [19], 'cancer': [20], '(NSCLC)': [21], 'and': [22, 51, 56, 98, 114, 162, 231, 238, 266, 278, 292], 'are': [23, 271], 'associated': [24], 'sensitivity': [26], 'to': [27, 96, 165, 222, 273, 287], 'treatment': [28, 61, 72, 248, 288], 'gefitinib': [30, 63, 74, 122, 198, 250], 'or': [31, 64, 75, 87, 123, 224, 251], 'erlotinib.': [32, 65, 124], 'Our': [33], 'study': [34], 'explored': [35], 'relationship': [37], 'between': [38, 229], 'two': [40, 105], 'most': [41], 'common': [42], 'types': [43], 'of': [44, 58, 206, 211, 261, 264, 268, 281], 'somatic': [45], 'EGFR': [46, 80, 116, 239, 283, 294], 'mutations,': [47], 'exon': [48, 84, 128, 176, 240], '19': [49, 85, 129, 177, 241], 'deletions': [50, 242], 'L858R': [53, 88, 142, 258], 'point': [54], 'mutation,': [55], 'outcomes': [57], 'following': [60, 247], 'Experimental': [66], 'Design:': [67], 'Tumor': [68], 'specimens': [69], 'obtained': [70], 'before': [71], 'erlotinib': [76, 201, 252], 'were': [77, 90, 101, 119, 152, 181], 'analyzed': [78], 'for': [79, 103, 171, 194], 'mutations.': [81], 'Patients': [82, 125, 235], 'deletion': [86, 130], 'identified.': [91], 'The': [92], 'response': [93, 157, 192], 'rate,': [94], 'time': [95, 164, 221], 'progression,': [97], 'overall': [99, 135, 225], 'survival': [100, 136, 226, 246], 'determined': [102], 'groups.': [106], 'Results:': [107], 'We': [108], 'identified': [109], '36': [110], 'NSCLC': [113, 237], 'an': [115, 127, 141, 175], 'mutation': [117, 143], 'who': [118], 'treated': [120, 196], 'had': [131], 'a': [132, 186, 244], 'significantly': [133], 'longer': [134, 245], 'compared': [137, 199, 253], '(38': [144], 'versus': [145, 160, 168, 209], '17': [146], 'months;': [147], 'P': [148, 214], '=': [149, 215], '0.04).': [150], 'There': [151], 'also': [153, 203], 'trends': [154], 'toward': [155], 'higher': [156], 'rate': [158, 193], '(73%': [159], '50%)': [161], 'improved': [163], 'progression': [166, 223], '(24': [167], '10': [169], 'months)': [170], 'deletion,': [178], 'although': [179], 'these': [180], 'not': [182], 'independently': [183], 'significant': [184], 'multivariate': [187], 'analysis.': [188], 'A': [189], 'difference': [190, 219], 'was': [202, 227], 'noted': [204, 228], '[18': [205], '23': [207], '(78%)': [208], '3': [210], '9': [212], '(33%);': [213], '0.04].': [216], 'No': [217], 'obvious': [218], 'gefitinib-': [230], 'erlotinib-treated': [232], 'patients.': [233], 'Conclusions:': [234], 'those': [255], 'mutation.': [259], 'Pooling': [260], 'greater': [262], 'numbers': [263], 'completion': [267], 'prospective': [269], 'trials': [270], 'needed': [272], 'further': [274], 'define': [275], 'predictive': [277], 'prognostic': [279], 'roles': [280], 'different': [282], 'respect': [286], 'gefitinib,': [290], 'erlotinib,': [291], 'other': [293], 'inhibitors.': [295]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168841302', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 32}, {'year': 2015, 'cited_by_count': 38}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 32}, {'year': 2012, 'cited_by_count': 32}], 'updated_date': '2024-12-19T07:43:38.990781', 'created_date': '2016-06-24'}