Publication Information

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3331, 3343, 3355, 3360, 3371, 3375, 3393, 3408, 3419, 3432, 3448, 3546, 3552, 3556, 3560, 3610, 3617, 3625, 3653, 3659, 3676, 3686, 3693, 3696, 3700, 3704, 3735, 3751, 3766, 3774, 3780, 3792, 3805, 3840, 3846, 3850, 3896, 3899, 3911, 3915, 3923, 3930, 3941, 3955, 3958, 3981, 3988, 3995, 4000, 4038, 4116, 4148, 4151, 4224, 4241, 4245, 4251, 4259, 4263, 4266, 4274, 4277, 4281, 4293, 4302, 4310, 4313, 4318, 4327, 4336, 4341, 4376, 4382, 4400, 4459, 4490, 4507, 4514, 4517, 4521, 4608, 4660, 4663, 4669, 4680, 4700, 4703, 4719, 4722, 4742, 4772, 4780, 4789, 4797, 4801, 4827, 4834, 4846, 4856, 4872, 4883, 4887, 4914, 4964, 4979, 5050, 5076, 5092, 5144, 5157, 5168, 5173, 5183, 5190, 5249, 5272, 5329, 5458, 5461], 'human': [7, 215, 471], 'pathogen': [8, 216], 'Streptococcus': [9, 217], 'pneumoniae,': [10, 218], 'is': [11, 128, 159, 164, 175, 219, 336, 367, 372, 383, 464, 475, 501, 771, 877, 1959, 2050, 2104, 2139, 2270, 2279, 2298, 2342, 2422, 2504, 2750, 3117, 3180, 3293, 3656, 3692, 3800, 3854, 3905, 3970, 4138, 4329, 4523, 4596, 4652, 4706, 4745, 4832, 4838, 4962, 4970, 5073, 5084, 5152, 5528], 'soluble': [13, 221], 'protein': [14, 95, 222, 303, 3697, 5011, 5147], 'that': [15, 66, 130, 167, 223, 274, 338, 375, 745, 784, 884, 1254, 1279, 2123, 2358, 2536, 2673, 2730, 3036, 3636, 3651, 3669, 3936, 3967, 4131, 4322, 4348, 4469, 4516, 4594, 4604, 4612, 4711, 4811, 4826, 4842, 4855, 4870, 4901, 4951, 4963, 5075, 5118, 5460], 'disrupts': [16, 224], 'cholesterol-containing': [17, 72, 225, 280, 1273], 'membranes': [18, 52, 174, 201, 226, 260, 382, 409, 1024, 3691, 4478, 4537, 4615, 5014, 5125], 'cells': [20, 228, 528], 'by': [21, 229, 579, 587, 680, 683, 1289, 1431, 1442, 1674, 1753, 1759, 1802, 1835, 1886, 2108, 2300, 2424, 2576, 3858, 3972, 4044, 4120, 4124, 4174, 4765, 5069, 5182], 'forming': [22, 230], 'ring-shaped': [23, 108, 231, 316, 892, 3514], 'oligomers.': [24, 232], 'Magic': [25, 233], 'angle': [26, 234, 419, 1151], 'spinning': [27, 235, 420, 1152], 'and': [28, 55, 57, 83, 106, 121, 193, 197, 236, 263, 265, 291, 314, 329, 401, 405, 433, 474, 496, 529, 546, 622, 636, 685, 894, 902, 956, 1016, 1105, 1178, 1186, 1249, 1263, 1326, 1367, 1504, 1518, 1579, 1597, 1607, 1621, 1624, 1656, 1689, 1735, 1783, 1813, 1841, 1868, 1897, 1919, 2166, 2188, 2248, 2278, 2397, 2442, 2517, 2556, 2656, 2822, 2829, 2842, 2853, 2863, 2926, 2962, 3004, 3018, 3096, 3120, 3140, 3145, 3183, 3207, 3212, 3417, 3475, 3529, 3554, 3566, 3645, 3703, 3866, 3935, 4020, 4048, 4122, 4215, 4265, 4320, 4399, 4451, 4499, 4603, 4645, 4721, 4770, 4910, 4973, 4985, 5009, 5058, 5102, 5106, 5134, 5146, 5195, 5248], 'wideline': [29, 237, 1085, 1517, 1627, 1733, 2383, 3713], 'static': [30, 238, 3325, 4001], '31P': [31, 239, 1086, 1149, 1709, 1873, 1933, 2014, 2054, 2384, 2784, 2868, 2902, 2939, 3714, 4002, 4282, 4670], 'NMR': [32, 63, 125, 240, 271, 333, 1012, 1087, 1248, 1520, 1747, 1874, 1934, 2385, 2749, 2785, 2904, 2941, 3136, 3203, 3715, 4003, 4284, 4639, 4672], 'have': [33, 241, 677, 1091, 3467, 4171, 4486, 4510, 5310, 5478], 'been': [34, 242, 584, 678, 1092, 1282, 4172, 4487, 4511, 5266, 5295, 5479], 'used': [35, 243, 1283, 1424, 1545, 1560, 1593, 1860, 1876, 2751, 3350, 4288, 4642], 'in': [36, 75, 110, 151, 244, 283, 318, 359, 507, 535, 776, 848, 888, 945, 1023, 1065, 1077, 1159, 1180, 1191, 1199, 1370, 1377, 1425, 1546, 1602, 1638, 1822, 1880, 1920, 1969, 2023, 2076, 2093, 2230, 2286, 2305, 2325, 2362, 2407, 2474, 2543, 2549, 2552, 2606, 2639, 2644, 2648, 2659, 2793, 2799, 2859, 2943, 2987, 3064, 3088, 3118, 3122, 3161, 3181, 3185, 3191, 3228, 3258, 3301, 3308, 3314, 3323, 3342, 3359, 3374, 3396, 3429, 3551, 3570, 3642, 3652, 3663, 3726, 3756, 3804, 3932, 3948, 3954, 3980, 3983, 3999, 4013, 4240, 4256, 4273, 4280, 4344, 4351, 4365, 4381, 4495, 4529, 4631, 4647, 4784, 4796, 4824, 4866, 4912, 5049, 5176, 5257, 5271], 'combination': [37, 178, 245, 386, 5087], 'with': [38, 71, 93, 140, 143, 246, 279, 301, 348, 351, 753, 792, 954, 1097, 1494, 1563, 1629, 1727, 1807, 1904, 2044, 2099, 2113, 2176, 2241, 2337, 2375, 2436, 2462, 2529, 2572, 2700, 2703, 2849, 2966, 3169, 3236, 3264, 3278, 3340, 3382, 3392, 3431, 3517, 3522, 3658, 3728, 3742, 3746, 3765, 3771, 3961, 4143, 4162, 4234, 4331, 4354, 4395, 4476, 4497, 4519, 4614, 4626, 4788, 4817, 5161, 5317, 5326, 5346, 5464], 'freeze-fracture': [39, 247, 1752, 4753, 5585], 'electron': [40, 98, 248, 306, 441, 626, 1250, 1850, 1857, 3347, 3368, 4754], 'microscopy': [41, 99, 249, 307, 442, 1251, 3348], 'to': [42, 203, 250, 411, 521, 629, 773, 886, 900, 1193, 1502, 1513, 1661, 1679, 1715, 1809, 1838, 1877, 1940, 2046, 2182, 2195, 2235, 2243, 2254, 2281, 2339, 2350, 2402, 2438, 2582, 2757, 2806, 2922, 3015, 3171, 3238, 3351, 3384, 3401, 3471, 3544, 3675, 3734, 3762, 3773, 3791, 3839, 3856, 3908, 3991, 3994, 4037, 4130, 4258, 4356, 4360, 4373, 4410, 4447, 4601, 4643, 4654, 4840, 5110, 5130, 5132, 5135, 5171, 5222, 5268, 5309, 5344, 5481, 5530, 5577], 'investigate': [43, 251], 'effect': [45, 169, 253, 377, 3687, 3695, 4847, 5313, 5433], 'pneumolysin': [47, 70, 134, 171, 255, 278, 342, 379, 642, 846, 876, 940, 1290, 1905, 1924, 1943, 2039, 2411, 2641, 2745, 2947, 2972, 3033, 3110, 3168, 3235, 3266, 3341, 3381, 3465, 3637, 3660, 3689, 3973, 4041, 4141, 4236, 4352, 4397, 4849, 5080, 5166, 5333], 'on': [48, 172, 256, 380, 1525, 2001, 2970, 3047, 3109, 3564, 3568, 3690, 3699, 4506, 4513, 4607, 4620, 4850, 4864, 4898, 5081, 5314, 5434, 5584], 'fully': [49, 257], 'hydrated': [50, 258, 1438], 'model': [51, 259, 1277], 'containing': [53, 261], 'cholesterol': [54, 262, 887, 1503, 3172, 3239, 4357], 'phosphatidylcholine': [56, 264, 461, 1364, 2273, 2986], 'dicetyl': [58, 266], 'phosphate': [59, 267, 1197, 2925], '(10:10:1': [60, 268], 'molar': [61, 269, 1373, 1500], 'ratio).': [62, 270], 'spectra': [64, 126, 272, 334, 1682, 1724, 1734, 2786, 2942, 3160, 3227, 3326, 3716, 4004, 4285], 'show': [65, 273, 2948, 3043, 3388, 3447, 4347], 'interaction': [68, 276, 953, 2110, 2321, 2856, 5191], 'liposomes': [73, 281, 1274, 1495, 2101, 2284, 3446, 3518, 3569, 3629, 4831], 'results': [74, 282, 681, 1245, 2548, 2643, 4012, 4364, 4960], 'formation': [77, 181, 204, 285, 389, 412, 519, 758, 1288, 2561, 3677, 3969, 4527, 4860, 5090, 5111], 'nonbilayer': [80, 90, 288, 298, 2459, 3344, 3679, 3710, 3744, 3901, 3959, 4134, 4252, 4297, 4369, 4704, 4723, 4743, 5474], 'phospholipid': [81, 150, 289, 358, 436, 754, 1067, 1095, 1882, 2034, 2074, 2541, 2766, 2847, 3787, 4378, 4391, 4403], 'phase': [82, 91, 290, 299, 1068, 1883, 3063, 3357, 3745, 3902, 3960, 4135, 4298, 4370, 4744], 'vesicle': [84, 292, 445, 447, 2105, 2840, 3433, 3670], 'aggregation.': [85, 293, 3441], 'The': [86, 146, 294, 354, 1572, 1590, 1641, 1693, 1843, 1932, 1953, 1991, 2048, 2086, 2116, 2151, 2208, 2226, 2260, 2291, 2330, 2414, 2495, 2684, 2714, 2796, 2813, 2975, 3024, 3050, 3091, 3245, 3270, 3297, 3386, 3442, 3712, 3754, 3893, 3952, 3976, 4030, 4111, 4154, 4247, 4270, 4454, 4697, 4752, 4852, 5137, 5302, 5523], 'amount': [87, 295, 2346, 4295], 'increases': [92, 300, 3030, 3288, 4255], 'increasing': [94, 302, 3265, 3962], 'concentration.': [96, 304, 2746, 3049], 'Freeze-fracture': [97, 305, 1782, 3346], 'indicates': [100, 308, 2696, 3966, 4321, 4950], 'coexistence': [102, 310, 3430, 3723], 'aggregated': [104, 312, 2285, 3389], 'vesicles': [105, 313, 1360, 1422, 1913, 1972, 1999, 2324, 3394, 3409, 3425, 4777, 4794, 4819], 'free': [107, 156, 189, 315, 364, 397, 1614, 4230, 4332, 4876, 5098, 5149, 5255, 5465], 'structures': [109, 317, 2078, 2473, 3452, 3474, 3515, 3550, 3727, 3934, 4035, 4158, 4228, 4814, 4984, 5477, 5527], 'presence': [112, 320, 1201, 1922, 2288, 2327, 2409, 2531, 2945, 3361, 3376, 3449, 3781, 3806, 3924, 4383, 4773, 5273], 'pneumolysin.': [114, 322, 1890, 2290, 2329, 3363, 5162], 'On': [115, 323, 4489], 'basis': [117, 325], 'their': [119, 327, 1181, 2135, 2223, 4021, 5533], 'size': [120, 328, 2081, 2096, 2126, 3397, 3470, 3558, 3612, 4024, 4039], 'analysis': [122, 330, 1285, 1671], 'it': [127, 335, 782, 899, 4837, 5348], 'concluded': [129, 166, 337, 374], 'rings': [132, 340, 3561, 3618, 3655, 4042, 4117, 4319, 4667, 4874, 4888], 'are': [133, 341, 850, 1252, 1275, 1712, 1928, 2000, 2742, 2791, 2831, 3176, 3243, 3426, 3519, 3555, 3777, 3938, 4393, 4463, 4685, 4763, 5067, 5220], 'oligomers': [135, 343, 3466, 3638, 4170, 4333, 4628, 5219, 5256, 5303, 5466], '(containing': [136, 344], '30–50': [137, 345], 'monomers)': [138, 346], 'complexed': [139, 347, 4524, 4625], 'lipid': [141, 173, 187, 349, 381, 395, 450, 1157, 1439, 1542, 1912, 1937, 2021, 2129, 2149, 2218, 2308, 2352, 2460, 2471, 2566, 2570, 2654, 2676, 2682, 2694, 2710, 2720, 2797, 3058, 3061, 3116, 3143, 3179, 3210, 3338, 3356, 3372, 3390, 3648, 3701, 3752, 3796, 3916, 3946, 4145, 4163, 4328, 4337, 4683, 4716, 4724, 4758, 4776, 4803, 4808, 4884, 5082, 5096, 5145, 5476], '(each': [142, 350], '840–1400': [144, 352], 'lipids).': [145, 353], 'lifetime': [147, 355], 'either': [152, 360, 4222], 'bilayer-associated': [153, 361], 'complexes': [154, 158, 362, 366, 2121, 2374, 2461, 4496, 5012, 5151], 'or': [155, 363, 455, 2702, 3073, 3412, 4164, 4479, 4741, 4820, 4865], 'pneumolysin-lipid': [157, 365], '>': [160, 368], '15': [161, 369, 1443, 4750], 'ms.': [162, 370, 4751], 'It': [163, 371, 4651, 5072], 'further': [165, 373, 3255, 3907], 'complex': [177, 385, 537, 5086], 'pore': [180, 388, 518, 757, 905, 1287, 4526, 4859, 5089], 'within': [182, 390, 906, 3059, 4833, 4956, 5013, 5091], 'bilayer,': [184, 392], 'extraction': [185, 393, 5094], 'into': [188, 396, 527, 764, 891, 1258, 1763, 3709, 4229, 4317, 4458, 4886, 5097], 'oligomeric': [190, 398, 635, 3480, 4140, 4873, 4983, 5099], 'complexes,': [191, 399, 5100], 'aggregation': [192, 400, 2106, 3644, 3671, 5101], 'fusion': [194, 402, 5103], 'liposomes,': [196, 404, 3565, 4233], 'destabilization': [199, 407, 5108], 'leading': [202, 410, 520, 5109], 'small': [206, 414, 1966, 2573, 4023, 4775, 4793, 5113], 'vesicles.': [207, 415, 5114], 'cholesterol-binding': [416, 482], 'toxin': [417, 883, 2112, 2348, 2803, 3048, 3291, 3298, 3481, 3963, 4412, 4470, 4522], 'magic': [418, 1150], 'full': [421], 'width': [422, 2010, 2261, 2510, 2590, 3848, 3894, 3913], 'at': [423, 1188, 1384, 1446, 1496, 1506, 1531, 1566, 1647, 1755, 1766, 1798, 1805, 1864, 1906, 1925, 2040, 2238, 2433, 2723, 2810, 2917, 2930, 2958, 2977, 3031, 3082, 3102, 3173, 3240, 3285, 3624, 4687, 4728, 4738, 4978], 'half-height': [424, 1189], 'isotropic': [425, 1182, 3113, 3129, 3196, 3260], 'chemical': [426, 428, 438, 1079, 1183, 1710, 2726, 2816, 2967, 2983, 3114, 3130, 3197, 3261], 'shift': [427, 429, 439, 1080, 2817, 2968, 2984], 'toxin-dependent': [432], 'toxin-free': [435, 4813], 'environment': [437, 2514, 2547, 2571, 2990, 3649, 4532, 4705], 'anisotropy': [440, 1081], 'large': [443, 4324, 4880, 5047, 5061, 5141, 5252], 'unilamellar': [444, 1359, 1971], 'multilamellar': [446], 'rate': [448, 457, 2137, 4730], 'exchange': [451, 2711, 4714], 'between': [452, 530, 1622, 1636, 2164, 2201, 2322, 2712, 2827, 3074, 3093, 3627, 4449, 4718, 4806], 'different': [453, 1098, 1926, 2719, 2765, 2788, 3165, 3232], 'phases': [454, 1096, 2478, 2699, 3811], 'environments': [456, 2695, 2721, 2741, 2767, 4635, 4725], 'rotational': [459], 'motion': [460, 2466, 3749], 'dicetylphosphate': [462, 1368], 'Pneumolysin': [463, 1449, 1491], 'from': [469, 489, 493, 1094, 1246, 1452, 1701, 1746, 1831, 1910, 1936, 2032, 2073, 2180, 2193, 2213, 2283, 2430, 2447, 2458, 2499, 2511, 2568, 2679, 2717, 2787, 2933, 3056, 3086, 3134, 3158, 3201, 3225, 3337, 3370, 3398, 3721, 3759, 3898, 3914, 4232, 4335, 4358, 4371, 4483, 4668, 4679, 4702, 4779, 4845, 5532], 'pathogenSteptococcus': [472], 'pneumoniae': [473], 'member': [477], 'family': [480], 'toxins': [483, 533], '(CBTs),1': [484], 'which': [485, 580, 743, 2006, 2356, 2728, 4235, 4485, 4520, 4917, 5332, 5347, 5456], 'also': [486, 3427, 3520, 4501, 5046, 5127, 5153, 5307, 5324], 'includes': [487], 'perfringolysin': [488, 597, 4509], 'Clostridium': [490], 'perfringens,': [491], 'listeriolysin': [492], 'Listeria': [494], 'monocytogenes,': [495], 'streptolysin': [497, 5264, 5305], 'fromStreptococcus': [498], 'pyogenes.': [499], 'Streptolysin': [500], 'well': [502, 516, 851, 878, 2697, 4675], 'known': [503, 772, 879, 5221], 'for': [504, 510, 574, 594, 845, 1019, 1284, 1509, 1561, 1612, 1664, 1718, 1731, 1738, 1751, 1861, 1995, 2020, 2468, 2760, 2872, 2897, 3164, 3231, 3802, 4115, 4659, 5155, 5299, 5581], 'its': [505, 1767, 3094, 3259, 3968], 'use': [506, 624], 'cell': [508, 5124], 'biology': [509], 'permeabilization': [512], 'cells.': [514], 'As': [515, 5163], 'as': [517, 880, 949, 1388, 1457, 2316, 2599, 2753, 3149, 3216, 3289, 3559, 3616, 4289, 4533, 5148, 5186], 'breakdown': [523], 'membrane': [525, 777, 794, 2758, 4885, 5065, 5107], 'barriers': [526], 'tissues,': [531], 'these': [532, 2120, 2500, 2740, 3472, 3933, 4034, 4830], 'act': [534, 582], 'manner': [538, 948], 'involving': [539, 5060], 'activation': [541, 5227, 5290, 5352], 'intracellular': [543], 'signaling': [544], 'pathways': [545], 'induction': [548, 1615], 'inflammation,': [550], 'among': [551], 'other': [552, 1269, 2341, 4802, 4818, 5300], 'responses': [553], '(see': [554, 1915, 2876, 3069, 3863], 'Morgan': [555, 1468, 4088, 4932, 5405], 'et': [556], 'al.': [557], '(1Morgan': [558], 'P.J.': [559, 1469, 4089, 4933, 5406], 'Andrew': [560, 655, 825, 861, 921, 961, 995, 1311, 1340, 1403, 1476, 3495, 3584, 4062, 4096, 4188, 4426, 4934, 5027, 5200, 5230, 5355, 5413], 'P.W.': [561, 656, 826, 862, 922, 962, 996, 1312, 1341, 1404, 1477, 3496, 3585, 4063, 4097, 4189, 4427, 4935, 5028, 5201, 5231, 5356, 5414], 'Mitchell': [562, 863, 987, 1303, 1470, 4090, 4936, 5407], 'T.J.': [563, 864, 960, 988, 1304, 1471, 4091, 4937, 5199, 5229, 5354, 5408], 'Rev.': [564, 1112, 2065, 3873], 'Med.': [565], 'Microbiol.': [566, 970, 5209, 5239, 5364], '1996;': [567, 1236], '7:': [568], '221-229Crossref': [569], 'Scopus': [570, 618, 669, 708, 739, 810, 839, 871, 935, 975, 1006, 1034, 1047, 1060, 1118, 1134, 1174, 1214, 1227, 1240, 1322, 1354, 1417, 1487, 1987, 2069, 2491, 2623, 2777, 2893, 3000, 3509, 3598, 3833, 3879, 4076, 4107, 4202, 4440, 4559, 4587, 4944, 5005, 5041, 5214, 5244, 5369, 5393, 5424, 5452, 5519, 5570], '(28)': [571], 'Google': [572, 620, 671, 710, 741, 812, 841, 873, 937, 977, 1008, 1036, 1049, 1062, 1120, 1136, 1146, 1176, 1216, 1229, 1242, 1324, 1356, 1419, 1489, 1989, 2071, 2493, 2625, 2635, 2779, 2895, 3002, 3511, 3600, 3820, 3835, 3881, 3891, 4078, 4109, 4204, 4442, 4561, 4589, 4946, 5007, 5043, 5216, 5246, 5287, 5371, 5395, 5426, 5454, 5521, 5572], 'Scholar)': [573, 621, 711, 1325, 2072, 3003, 5008, 5044], 'review).': [575], 'Understanding': [576], 'mechanisms': [578, 844, 5159], 'CBTs': [581, 640, 751, 1262, 4462, 4611, 4899, 5119], 'has': [583, 1280, 2980, 3698, 5167, 5265, 5293, 5339, 5430], 'greatly': [585, 2082], 'assisted': [586], 'determination': [589], 'crystal': [592], 'structure': [593, 3608], 'soluble,': [595], 'monomeric': [596, 5318], '(2Rossjohn': [598], 'J.': [599, 652, 694, 722, 803, 822, 918, 992, 999, 1108, 1308, 1315, 1337, 1400, 1463, 1480, 2886, 3492, 3581, 3869, 4059, 4083, 4100, 4185, 4207, 4210, 4423, 4545, 4570, 4939, 4996, 5000, 5024, 5280, 5374, 5400, 5417, 5441, 5445, 5447, 5507, 5558], 'Feil': [600, 5375], 'S.C.': [601, 5376], 'McKinstry': [602, 5377], 'W.J.': [603, 5378], 'Tweten': [604, 684, 701, 727, 1466, 4086, 4552, 4575, 5379, 5403], 'R.K.': [605, 702, 728, 982, 1298, 1467, 4087, 4553, 4576, 5380, 5404], 'Parker': [606, 653, 695, 723, 823, 919, 993, 1309, 1338, 1401, 1464, 3493, 3582, 4060, 4084, 4186, 4424, 4546, 4571, 5025, 5381, 5401], 'M.W.': [607, 654, 696, 724, 824, 920, 994, 1310, 1339, 1402, 1465, 3494, 3583, 4061, 4085, 4187, 4425, 4547, 4572, 5026, 5382, 5402], 'Cell.': [608, 659, 729, 829, 925, 1344, 1407, 3499, 3588, 4066, 4192, 4430, 4577, 5031, 5383], '1997;': [609, 2889, 5384], '89:': [610, 5385], '685-692Abstract': [611, 5386], 'Full': [612, 614, 663, 665, 733, 735, 833, 835, 929, 931, 1348, 1350, 1411, 1413, 3503, 3505, 3592, 3594, 4070, 4072, 4196, 4198, 4434, 4436, 4581, 4583, 5035, 5037, 5387, 5389, 5513, 5515, 5564, 5566], 'Text': [613, 615, 664, 666, 734, 736, 834, 836, 930, 932, 1349, 1351, 1412, 1414, 3504, 3506, 3593, 3595, 4071, 4073, 4197, 4199, 4435, 4437, 4582, 4584, 5036, 5038, 5388, 5390, 5514, 5516, 5565, 5567], 'PDF': [616, 667, 737, 837, 933, 1352, 1415, 3507, 3596, 4074, 4200, 4438, 4585, 5039, 5391, 5517, 5568], 'PubMed': [617, 668, 707, 738, 809, 838, 870, 934, 974, 1005, 1033, 1046, 1059, 1117, 1133, 1173, 1213, 1226, 1239, 1321, 1353, 1416, 1486, 1986, 2490, 2622, 2776, 2892, 2999, 3508, 3597, 3832, 3878, 4075, 4106, 4201, 4439, 4558, 4586, 4943, 5004, 5040, 5213, 5243, 5286, 5368, 5392, 5423, 5451, 5518, 5569], '(400)': [619, 5394], 'cryo-microscopy': [627], '(cryo-EM)': [628], 'obtain': [630, 3352, 4655], 'three-dimensional': [631], 'reconstructions': [632], 'pore-forming': [637, 882], 'states': [638], 'using': [641, 712, 1268, 1291, 1550, 1683, 4921], '(3Gilbert': [643, 909, 1328, 1391, 3483, 3572, 4050, 4176, 4414, 5015], 'R.J.C.': [644, 814, 910, 980, 1296, 1329, 1392, 1461, 3484, 3573, 4051, 4081, 4177, 4415, 5016, 5398], 'Jiménez': [645, 815, 911, 1330, 1393, 3485, 3574, 4052, 4178, 4416, 5017], 'J.L.': [646, 816, 912, 1331, 1394, 3486, 3575, 3825, 4053, 4179, 4417, 5018], 'Chen': [647, 817, 913, 1332, 1395, 3487, 3576, 4054, 4180, 4418, 5019], 'S.': [648, 818, 914, 1333, 1396, 3488, 3577, 4055, 4181, 4213, 4419, 4998, 5020, 5278], 'Tickle': [649, 819, 915, 1334, 1397, 3489, 3578, 4056, 4182, 4420, 5021], 'I.': [650, 820, 916, 1335, 1398, 3490, 3579, 4057, 4183, 4421, 5022, 5506, 5557], 'Rossjohn': [651, 693, 721, 821, 917, 991, 1307, 1336, 1399, 1462, 3491, 3580, 4058, 4082, 4184, 4422, 4544, 4569, 5023, 5399], 'Saibil': [657, 827, 923, 1342, 1405, 3497, 3586, 4064, 4190, 4428, 5029], 'H.R.': [658, 828, 924, 1343, 1406, 3498, 3587, 4065, 4191, 4429, 5030], '1999;': [660, 730, 830, 926, 1002, 1318, 1345, 1408, 3500, 3589, 4067, 4193, 4431, 4578, 5032, 5510, 5561], '97:': [661, 831, 927, 1346, 1409, 3501, 3590, 4068, 4194, 4432, 5033], '647-655Abstract': [662, 832, 928, 1347, 1410, 3502, 3591, 4069, 4195, 4433, 5034], '(164)': [670, 840, 936, 1355, 1418, 3510, 3599, 4077, 4203, 4441, 5042], 'Scholar).': [672, 842, 874, 938, 1009, 1063, 1147, 1243, 1357, 1420, 1490, 1789, 1990, 2494, 2636, 2780, 3512, 3601, 3836, 3892, 4110, 4205, 4590, 4947, 5217, 5427, 5522, 5573], 'These': [673, 2310, 3542, 4792, 5115], 'direct': [674, 1015], 'structural': [675], 'insights': [676, 1257, 4455], 'augmented': [679], 'obtained': [682, 1726], 'co-workers': [686], '(4Shepard': [687, 4538], 'L.A.': [688, 720, 4539, 4568], 'Heuck': [689, 717, 4540, 4565], 'A.P.': [690, 718, 4541, 4566], 'Hamman': [691, 4542], 'B.D.': [692, 4543], 'Ryan': [697, 4548], 'K.R.': [698, 4549], 'Johnson': [699, 725, 4550, 4573], 'A.E.': [700, 726, 4551, 4574], 'Biochemistry.': [703, 1042, 1055, 1169, 1209, 1222, 1235, 2772, 2995, 4554], '1998;': [704, 806, 867, 1030, 1483, 4103, 4555, 4940, 5001, 5420], '37:': [705, 4556], '14563-14574Crossref': [706, 4557], '(268)': [709, 4560], 'fluorescence': [713, 4504, 4621], 'spectroscopy': [714], '(5Shatursky': [715], 'O.': [716, 998, 1314, 1479, 4099, 4564, 5416], 'Shepard': [719, 4567], '99:': [731, 4579], '293-299Abstract': [732, 4580], '(308)': [740, 4588], 'Scholar),': [742, 1177, 4443, 5247, 5288, 5455], 'demonstrate': [744], 'pendant': [747], 'domain': [748, 770, 5330], 'interacts': [752, 4237, 5349], 'molecules': [755, 2219, 2236, 2255, 2431, 2848, 4392, 4404, 4413, 4717], 'during': [756, 1570, 1618, 1626, 1650, 5350], 'via': [759, 779], 'two': [760, 765, 789, 2209, 2390, 2949, 3007, 3628, 4681], 'α-helix': [761], 'bundles': [762], 'refolded': [763], 'β-hairpins.': [766], 'A': [767, 1555, 1853, 3078, 3647, 4891], 'second': [768, 2173], 'terminal': [769], 'be': [774, 1071, 1163, 2314, 2597, 3545, 3673, 4160, 4287, 4445, 4618, 4641, 4919, 5223, 5482], 'involved': [775], 'binding': [778], 'cholesterol.': [780, 2047, 3385, 4502], 'Thus,': [781], 'seems': [783], 'CBT': [786, 4508, 4627], 'mechanism': [787, 1260, 4460, 4857], 'involves': [788, 4862], 'domains': [790], 'interacting': [791, 4783], '(6Nakamura': [795], 'M.': [796, 2879, 3823, 4988, 4994, 5494, 5545], 'Sekino-Suzuki': [797], 'N.': [798, 1473, 4093, 5410, 5498, 5549], 'Mitsui': [799], 'K.-I.': [800, 802], 'Ohino-Iwashita': [801], 'Biochem.': [804, 4938, 5446], '(Tokyo).': [805], '123:': [807], '1145-1155Crossref': [808], '(44)': [811], 'Scholar,3Gilbert': [813], 'Two': [843, 4674], 'action': [847, 5078], 'disease': [849], 'defined': [852], '(7Alexander': [853], 'J.E.': [854], 'Berry': [855], 'A.M.': [856], 'Paton': [857], 'J.C.': [858], 'Rubins': [859], 'J.B.': [860], 'Microb.': [865], 'Pathog.': [866], '24:': [868], '167-174Crossref': [869], '(43)': [872], 'First,': [875], 'binds': [885], 'membranes,': [889, 4913, 5105], 'oligomerizes': [890], 'assemblies,': [893], 'undergoes': [895, 3252], 'conformational': [896], 'changes': [897, 1179, 1879, 3755], 'causing': [898], 'penetrate': [901], 'form': [903, 3066, 4955], 'bilayer': [908, 1161, 2364, 2513, 2989, 3062, 3142, 3209, 4477, 4480, 4531, 4720, 4868, 5051], 'Secondly,': [939], 'activates': [941, 5334], 'complement': [943, 957, 1264, 5174, 5196, 5226, 5270, 5292, 5315, 5335, 5351, 5435], 'system': [944, 1278, 3373, 3553, 5175], 'nonimmunospecific': [947, 5178, 5289], 'result': [951, 2282, 2318, 2858, 4239, 4844, 5188, 5531], 'IgG-Fc': [955], 'proteins': [958, 1203], '(8Mitchell': [959, 5198, 5228, 5353], 'Saunders': [963, 5202, 5232, 5357], 'F.K.': [964, 5203, 5233, 5358], 'Smith': [965, 5204, 5234, 5359], 'A.N.': [966, 5205, 5235, 5360], 'Boulnois': [967, 5206, 5236, 5361], 'G.J.': [968, 5207, 5237, 5362], 'Mol.': [969, 1000, 1316, 1481, 3826, 4101, 5208, 5238, 5363, 5418], '1991;': [971, 5210, 5240, 5365], '5:': [972, 5211, 5241, 5366], '1883-1888Crossref': [973, 5212, 5242, 5367], '(128)': [976, 5215, 5245, 5370], 'Scholar,': [978, 1037, 1050, 1121, 1137, 1217, 1230, 2626, 3821, 3882, 4079, 4562, 5372, 5396], '9Gilbert': [979], 'Heenan': [981, 1297], 'Timmins': [983, 1299], 'P.A.': [984, 1300], 'Gingles': [985, 1301], 'N.A.': [986, 1302], 'Rowe': [989, 1305, 1474, 4094, 5411], 'A.J.': [990, 1306, 1475, 4095, 5412], 'Byron': [997, 1313, 1478, 4098, 5415], 'Biol.': [1001, 1140, 1317, 1482, 2629, 3814, 3828, 3885, 4102, 5419, 5508, 5559], '293:': [1003, 1319], '1145-1160Crossref': [1004, 1320], '(40)': [1007, 1323], 'Solid': [1010], 'state': [1011, 4638], 'provides': [1013], 'quantitative': [1017, 2761], 'way': [1018], 'investigating': [1020], 'lipid-protein': [1021], 'interactions': [1022], '(10Watts': [1025], 'A.': [1026, 1041, 1054, 1110, 1168, 1208, 1221, 2771, 2994, 3871], 'Biochim.': [1027, 1127, 1980, 2484, 2616], 'Biophys.': [1028, 1113, 1128, 1981, 2485, 2617, 3874], 'Acta.': [1029, 1129, 1982, 2486, 2618], '1376:': [1031], '297-318Crossref': [1032], '(83)': [1035], '11Pinheiro': [1038], 'T.J.T.': [1039, 1166, 1206, 2769, 2992], 'Watts': [1040, 1053, 1167, 1207, 1220, 2770, 2993], '1994;': [1043, 1170, 1210, 2773, 2996], '33:': [1044, 1171, 1211, 2774, 2997], '2459-2467Crossref': [1045, 1172, 1212, 2775, 2998], '(85)': [1048, 1175, 1215, 2778, 3001], '12Spooner': [1051, 1218], 'P.J.R.': [1052, 1219], '1992;': [1056, 1223], '31:': [1057, 1224], '10129-10138Crossref': [1058, 1225], '(72)': [1061, 1228], 'Changes': [1064], 'protein-induced': [1066], 'behavior': [1069, 1884, 2671], 'can': [1070, 1162, 2313, 4286, 4444, 4640], 'observed': [1072, 1093, 2315, 2406, 2814, 3322, 3464, 3521, 4043, 4173, 4686], 'through': [1073, 5331], 'characteristic': [1074, 2051, 2206, 2271, 2690, 2982, 4126], 'intensity': [1075, 1694, 2253, 2332, 2396, 2650, 2661, 3080, 3095, 3098, 3147, 3156, 3214, 3223, 3272, 3281, 3303, 3316, 3757, 3844, 3852, 4249, 4275, 4306], 'distribution': [1076, 2192, 2216, 2251, 2567, 2595, 2610, 2655, 3758, 3764, 3853, 3918, 4128], '(CSA)-dominated': [1082], 'lineshapes': [1083, 1090], 'spectra.': [1088, 1707, 1741, 4673], 'Characteristic': [1089], 'modes': [1099], 'molecular': [1101, 3788], 'motions': [1102, 1198], '(Fig.': [1103, 1944, 2199, 2412, 2666, 2952, 3249, 3327, 3458, 3537, 3717, 4136, 4694, 4760, 4889], '1': [1104, 2132, 3865], 'Refs.': [1106, 3867], '13Seelig': [1107, 3868], 'Seelig': [1109, 3870], 'Q.': [1111, 3872], '1980;': [1114, 1983, 3875, 5448], '13:': [1115, 3876], '19-61Crossref': [1116, 3877], '(633)': [1119, 3880], '14Cullis': [1122], 'P.R.': [1123, 1976, 2480, 2612], 'de': [1124, 1977, 2481, 2613], 'Kruijff': [1125, 1978, 2482, 2614], 'B.': [1126, 1979, 2483, 2615], '1979;': [1130, 2487, 2619], '559:': [1131, 2488, 2620], '399-420Crossref': [1132, 2489, 2621], '(1516)': [1135, 2492, 2624], '15Yeagle': [1138, 2627, 3883], 'P.L.': [1139, 2628, 3813, 3884], 'Magn.': [1141, 2630, 2887, 3815, 3886], 'Reson.': [1142, 2631, 2888, 3816, 3887], '1990;': [1143, 2632, 3817, 3888], '9:': [1144, 2633, 3818, 3889], '1-50Crossref': [1145, 2634, 3819, 3890], 'Using': [1148], '(MAS)': [1153], 'NMR,': [1154], 'individual': [1156, 1697], 'components': [1158, 5066, 5197], 'resolved': [1164, 4676], '(11Pinheiro': [1165, 1205, 2768, 2991], 'shift,': [1184, 2727, 3262], 'CSA': [1185, 1958, 2015, 2147, 2179, 2401, 2522, 2555, 2575, 2605, 2733, 2869, 3732, 3736], 'full-width': [1187], '(FWHH)': [1190], 'response': [1192, 5472], 'modulation': [1194], 'determined': [1204, 3157, 3224], '16Carbone': [1231], 'M.A.': [1232, 5502, 5553], 'Macdonald': [1233], 'P.M.': [1234], '35:': [1237], '3368-3378Crossref': [1238], '(51)': [1241], 'Here': [1244], 'solid-state': [1247], 'presented': [1253, 4343], 'provide': [1255], 'novel': [1256], 'data': [1265, 1514, 4592, 4853], 'already': [1266, 1281], 'acquired': [1267], 'techniques.': [1270], 'Suspensions': [1271], 'small-angle': [1292], 'neutron': [1293], 'scattering': [1294], '(9Gilbert': [1295], 'cryo-EM': [1327, 4049, 4175], 'Large': [1358], '(LUVs)': [1361], 'egg-yolk': [1363], '(PC),': [1365], 'cholesterol,': [1366, 1896], '(DCP)': [1369], '10:10:1': [1372], 'ratio': [1374, 1900, 2361, 3092], 'were': [1375, 1429, 1522, 1544, 1600, 1610, 1725, 1749, 1846, 1902, 5306], 'prepared': [1376, 1430, 1750], '100': [1378, 2084, 2873], 'mm': [1379, 1386], 'Tris': [1380], 'buffer,': [1381], 'pH': [1382], '7.5,': [1383], '5': [1385, 1539, 2181, 3365, 3459, 3538, 3603, 3621, 3665, 3985, 4761], 'concentration': [1387, 2642, 2973, 3267, 3292, 3964, 4353], 'previously': [1389, 1458, 3567], 'described': [1390, 1459], 'Multilamellar': [1421], '(MLVs)': [1423], 'control': [1427, 2369, 2901], 'experiment': [1428, 2905], 'five': [1432], 'cycles': [1433], 'rapid': [1435, 1761, 4242, 4766], 'freezing': [1436, 4769], 'mixtures': [1440, 2790], 'followed': [1441, 1758, 1801], 'min': [1444, 1511], 'equilibration': [1445, 1754], '40': [1447, 1595], '°C.': [1448, 1908], 'was': [1450, 1492, 1559, 1576, 1587, 1594, 1645, 1659, 1672, 1699, 1796, 1829, 1859, 1875, 3349], 'expressed': [1451], 'recombinant': [1453], 'Escherichia': [1454], 'coliand': [1455], 'purified': [1456], '(17Gilbert': [1460], 'Errington': [1472, 4092, 5409], '284:': [1484, 4104, 5421], '1223-1237Crossref': [1485, 4105, 5422], '(68)': [1488, 4108, 5425], 'mixed': [1493], 'variety': [1498, 4633], 'ratios': [1501], 'incubated': [1505, 1903], '37': [1507], '°C': [1508, 1663, 3175, 3242], '10': [1510, 1736], 'prior': [1512, 1939], 'acquisition.': [1515, 1571], 'Phosphorus-31': [1516, 2747], 'MAS': [1519, 1619, 1654, 1669, 1740, 2748, 2783, 2871, 2903, 2940, 3135, 3202, 4283, 4671], 'measurements': [1521], 'carried': [1523, 4896], 'out': [1524, 4897], 'CMX': [1527], 'Infinity': [1528], '500': [1529, 1536, 4739], 'spectrometer': [1530], 'proton': [1533, 1568, 1584, 2861], 'frequency': [1534, 1569], 'MHz.': [1537], 'Typically': [1538], 'μmol': [1540], 'dispersion': [1543, 2035], '4-mm': [1548], 'rotor': [1549], 'an': [1551, 2189, 2371, 2836, 2906, 2963, 3523, 3530, 3783, 3949, 4139, 4349, 4366, 4648, 5470], 'HX': [1552], 'Apex': [1553], 'probe.': [1554], 'single': [1556, 1950, 2808, 3411], '90°': [1557, 1573, 2715, 3767], 'pulse': [1558, 1574], 'detection': [1562], 'broadband': [1564], 'decoupling': [1565, 1585, 2852, 2862], 'length': [1575], '4': [1577, 3250], 'μs,': [1578, 1596], 'strength': [1581], 'field': [1586, 2247, 2441], '20': [1588], 'kHz.': [1589], 'dwell': [1591], 'time': [1592], '2048': [1598], 'points': [1599], 'collected': [1601], 'each': [1603, 1613, 2340, 4396], 'experiment.': [1604], 'Between': [1605], '300': [1606], '3000': [1608], 'transients': [1609], 'averaged': [1611, 2057, 3731], 'decay': [1616], '(FID)': [1617], 'experiments': [1620, 1628, 1748, 4895], '5000': [1623], '10,000': [1625], '5-s': [1631], 'delay': [1632], '(exceeding': [1633], '5T': [1634], '1)': [1635], 'acquisitions': [1637], 'all': [1639, 1665, 3987], 'cases.': [1640], 'sample': [1642, 1828], 'rotation': [1643, 1963, 2538, 3928], 'speed': [1644, 1668, 2782], 'maintained': [1646], '12': [1648], 'kHz': [1649, 2144], 'acquisition': [1651], 'spectra,': [1655], 'temperature': [1658], 'set': [1660], '30': [1662, 1907, 3174, 3241, 4409], 'experiments.': [1666], 'High': [1667, 2781], 'lineshape': [1670], 'performed': [1673, 1797], 'fitting': [1675], 'simulated': [1676, 1706], 'Lorentzian': [1677], 'lines': [1678, 1698], 'experimental': [1681], 'Spinsight': [1684], '(Chemagnetics,': [1685], 'Fort': [1686], 'Collins,': [1687], 'CO)': [1688], 'Felix': [1690], '(MSI,': [1691], 'Cambridge).': [1692], 'estimated': [1700, 4446], 'integral': [1703], 'All': [1708, 1723, 2938], 'shifts': [1711, 3131, 3198], 'measured': [1713, 2498, 2520], 'relative': [1714, 2331, 2395, 2646, 3146, 3213, 3271, 4248, 4294], '0': [1716], 'ppm': [1717, 2168, 2184, 2198, 2932, 2961, 2979, 3017, 3022, 3084, 3104, 3287, 4693, 4737], '10%': [1719], 'v/v': [1720], 'phosphoric': [1721], 'acid.': [1722], '50': [1728, 3535, 4411], 'Hz': [1729, 1737, 4735], 'linebroadening': [1730], 'Samples': [1742], 'LUV': [1744], 'suspensions': [1745], 'room': [1756], 'temperature,': [1757], 'immersion': [1762], 'liquid': [1764], 'butane': [1765], 'solidification': [1768], 'point': [1769], '(18Severs': [1770], 'N.J.': [1771, 1777], 'Newman': [1772], 'T.M.': [1773], 'Shotton': [1774, 1778, 5580], 'D.M.': [1775, 1779], 'Severs': [1776], 'Rapid': [1780], 'Freezing,': [1781], 'Deep': [1784], 'Etching.': [1785], 'Wiley-Liss,': [1786], 'NY1995:': [1787], '31-50Google': [1788], 'Fracture': [1790], 'immobilized': [1793], 'frozen': [1794], 'droplets': [1795], '−100': [1799], '°C,': [1800], 'platinum': [1803], 'shadowing': [1804], '45°': [1806], 'respect': [1808, 2045, 2242, 2338, 2437, 3170, 3237, 3383, 3772, 4355], 'fractured': [1811], 'surface': [1812], 'normal': [1815], 'deposition': [1816], 'uniform': [1819], 'carbon': [1820], 'film': [1821], 'Balzers': [1824], 'freeze-etching': [1825], 'apparatus.': [1826], 'Residual': [1827], 'removed': [1830], 'carbon-platinum': [1833, 1844], 'replicas': [1834, 1845], 'cyclic': [1836], 'exposure': [1837], 'potassium': [1839], 'hypochlorate': [1840], 'methanol.': [1842], 'transferred': [1847], 'onto': [1848], 'copper': [1849], 'microscope': [1851, 1858], 'grids.': [1852], 'Phillips': [1854], 'CM120': [1855], 'transmission': [1856, 3367], 'grid': [1862], 'visualization': [1863], '100-kV': [1865], 'accelerating': [1866], 'voltage': [1867], '45,000': [1869], '×': [1870], 'magnification.': [1871], 'Wideline': [1872], 'monitor': [1878], 'induced': [1885, 2107, 3971], 'addition': [1888, 1941, 2037, 3838], 'LUVs': [1891, 2875, 3119, 3182], 'egg': [1893], 'yolk': [1894], 'PC,': [1895], 'DCP': [1898, 2304, 2830, 2934, 3087], '(molar': [1899], '10:10:1)': [1901], 'Spectra': [1909], 'alone': [1914], 'Fig.': [1916, 2026, 2154, 2419, 2794, 3162, 3229, 3364, 3602, 3620, 3664, 3864, 3984, 4006], '2': [1917, 1945, 2027, 2155, 2420, 3163, 3230, 3862], 'a)': [1918, 1946, 2103, 4762], 'concentrations': [1927, 3166, 3233], 'shown': [1929, 2792, 3662, 3979, 5480], '(Fig.2,': [1930, 2354, 3974], 'b–d).': [1931, 3329, 3975], 'spectrum': [1935, 2031, 2049, 2152, 2386, 3897], 'suspension': [1938, 2353, 2380, 2798, 2908], 'consists': [1947, 3005], 'narrow': [1951, 2292, 2525, 3246, 4267], 'line.': [1952], 'collapse': [1954], 'phosphorus': [1957], 'because': [1960, 2134, 2834, 4166, 4466, 4623, 5328, 5473], 'fast': [1962, 2537, 3926, 4027], 'relatively': [1965, 4022], '(<100': [1967], 'nm': [1968, 2874, 3455, 3528, 3536], 'diameter)': [1970, 3615], '(19Burnell': [1973], 'E.E.': [1974], 'Cullis': [1975], '603:': [1984], '63-69Crossref': [1985], '(177)': [1988], 'correlation': [1992], 'times': [1993, 4748], '(τR)': [1994], 'tumbling': [1996, 2841, 3739], 'such': [1998, 4157, 4227, 4812, 4968, 5526], 'order': [2003], '10−4–10−5s,': [2005], 'exceeds': [2007, 2131, 2518], 'inverse': [2009], 'average': [2013, 2080, 2125, 3942], '(∼40–50': [2016], 'ppm,': [2017, 2920], '∼6': [2018], 'kHz)': [2019], 'phosphates': [2022, 2302], 'extended': [2024, 2077, 2445, 3124, 3187], 'bilayers.': [2025, 3188], 'b': [2028, 2156, 2421, 3604], 'shows': [2029, 2672, 3366, 3606], 'after': [2036], '0.5': [2041, 4359], 'mol': [2042, 3379, 4362, 4386], '%': [2043, 3380, 4363, 4387], 'CSA-dominated': [2055, 3851], 'spherically': [2056, 3730], '(powder)': [2058], 'pattern': [2059, 2163, 2175, 2266, 2294, 2527], '(20Pake': [2060], 'G.E.': [2061], 'Purcell': [2062], 'E.M.': [2063], 'Physiol.': [2064], '1948;': [2066], '74:': [2067], '1184Crossref': [2068], '(98)': [2070], 'bilayers': [2075, 3416, 3702, 5083], 'exceeding': [2083, 4749], 'nm.': [2085], 'most': [2087, 2832, 3334, 3477, 4112], 'likely': [2088, 2280, 2833, 3335, 4113], 'cause': [2089, 5128], 'this': [2091, 3274, 3305, 4595, 5261], 'change': [2092, 3257], 'apparent': [2094], 'liposome': [2095, 3436, 3643], 'when': [2097, 3276, 5436], 'compared': [2098, 3277, 5316], 'protein-free': [2100], '(Fig.2': [2102], 'membranes.': [2115, 4851, 4957], 'motional': [2117, 2737, 4018], 'properties': [2118], 'indicate': [2122, 4900, 4961], 'aggregates': [2130, 2274, 2542], 'μm': [2133], 'reorientation': [2136, 2277], '(τR−1)': [2138], 'much': [2140, 4731], 'lower': [2141, 4657], 'than': [2142, 2506, 3940, 4733], '6': [2143], '(the': [2145, 5336], 'effective': [2146, 2178, 2378, 2400, 2496, 2521, 2554, 2574, 2604, 2732], 'phosphates).': [2150], 'reveals': [2157], 'three': [2158], 'overlapping': [2159, 3008], 'features,': [2160], 'powder': [2162, 2174, 2210, 2232, 2265, 2293, 2311, 2335, 2391, 2404, 2526, 2664, 3320, 3917, 3997, 4268], '∼27': [2165], '−14': [2167], '(below': [2169, 2267], 'dotted': [2170, 2268], 'line),': [2171, 2187], 'reduced': [2177, 3906], '−2': [2183], '(above': [2185, 2295], 'dashed': [2186, 2203, 2296], 'inverted': [2190, 2415, 2475, 3808, 3996], 'powder-like': [2191, 2416, 2455], '3': [2194], 'about': [2196, 2222, 3354, 3534], '−8': [2197], '2,': [2200, 2667, 3328, 3718, 4007], 'dottedand': [2202], 'lines,': [2204, 4677], 'see': [2205], 'lineshapes).': [2207], 'patterns': [2211, 2233, 2336, 2392, 2405, 2456, 2501, 2665], 'arise': [2212, 2457], 'spherical': [2215, 2581, 2609], 'rapidly': [2220], 'rotating': [2221], 'long': [2224], 'axes.': [2225], 'downfield': [2227, 2444, 2956], 'intense': [2228], 'feature': [2229, 2417, 4254], 'corresponds': [2234, 4036], 'oriented': [2237, 2256, 2432, 2449], '90': [2239, 2434], 'degrees': [2240, 2435], 'external': [2245, 2440], 'magnetic': [2246, 2452], 'upfield': [2250, 2427, 2964, 3247, 3256, 3332, 3770, 4278], 'along': [2257, 2450, 4816], 'field.': [2259, 2453], 'broader': [2264, 3028, 3051], 'line)': [2269, 2297], 'undergoing': [2275], 'slow': [2276, 2705], 'generated': [2299], 'same': [2307, 2725, 2911, 3557, 3611], 'bilayer.': [2309, 3090, 4338], 'distributions': [2312], 'independent': [2343, 2743], 'added': [2349], 'b–d),': [2355, 2954], 'suggests': [2357, 2535, 2729, 3635, 3668, 3922, 4710, 5457], 'PC/DCP': [2360], 'remains': [2365], 'constant.': [2366], 'In': [2367, 2585, 2899, 3837, 4221, 4339], 'experiment,': [2370], 'MLV': [2372, 2907], '(large': [2373], 'τR−1': [2376], '≫': [2377], 'CSA)': [2379], 'produced': [2381, 2913, 4764], '(Fig.3)': [2387], 'consisting': [2388, 4407], 'comparable': [2394], 'similar': [2399, 3469, 4129, 5343], '2).': [2413], 'characterized': [2423], 'sharp': [2426], 'edge,': [2428], 'arising': [2429, 4678], 'region': [2446], 'lipids': [2448, 3931, 4518, 4624, 4986, 5462], 'Inverted': [2454], 'cylindrical': [2463, 2583, 2653, 2675], 'symmetry': [2464], 'like,': [2467], 'example,': [2469, 3803], 'tubular': [2472], 'hexagonal': [2476, 3809], '(HII)': [2477, 3810], '(14Cullis': [2479, 2611], 'CSA,': [2497], '(∼11': [2502], 'ppm),': [2503], 'less': [2505], 'expected': [2508, 3855], 'half-spectral': [2509], '(∼40': [2515, 3919], 'ppm)': [2516, 3904], '(associated': [2528], 'DCP).': [2533], 'This': [2534, 2670, 3634, 3667, 3798, 3921, 4709, 4948, 5180], 'axially': [2545, 2593, 3548, 3747], 'symmetric': [2546, 2565, 2594, 3549, 3748], 'additional': [2550, 3784], 'reduction': [2551, 2579], 'excludes': [2557], 'possibility': [2559, 5459], 'cylindrically': [2564], 'simple': [2578], 'symmetry.': [2584], 'latter': [2587], 'case,': [2588], 'would': [2596, 4025, 4238, 5575], 'derived': [2598, 4482, 4778], 'half': [2601], 'related': [2608, 3674], 'Further': [2637], 'increase': [2638, 2647, 3300, 3313, 3953, 4272, 4350, 4367], 'decrease': [2658, 3857], 'both': [2663, 4167, 4262], 'cand': [2668], 'd).': [2669], 'population': [2677], 'arises': [2678, 3055, 3085, 3336], 'pneumolysin-associated': [2681, 3057], 'environment.': [2683, 3345], 'good': [2685], 'spectral': [2686, 3155, 3222, 3843, 3912, 4127, 4253, 4305], 'definition': [2687], 'edges': [2691, 2716], 'separated': [2698], 'none': [2701], 'very': [2704, 5342], '(τex−1': [2706], '<': [2707], '200': [2708], 'Hz),': [2709], 'them.': [2713], 'remain': [2722, 4474], 'and,': [2734], 'therefore,': [2735, 3053], 'characteristics': [2738, 3989], 'here': [2752, 3563, 4119, 4457], 'high-resolution': [2755], 'approach': [2756], 'studies': [2759, 4505], 'characterization': [2762], 'lipid-pneumolysin': [2789], '4.': [2795], 'absence': [2801, 3420], 'gives': [2804], 'rise': [2805, 3993], 'resonance': [2809, 2820, 2916, 2929, 2965, 2976, 3029, 3040, 3081, 3105, 3144, 3211, 3248, 3275, 3306, 3333, 4279, 4701], '∼0': [2811], 'ppm.': [2812, 4708], 'unusual': [2815], 'line': [2821, 3284], 'lack': [2824], 'resolution': [2826], 'PC': [2828, 2924, 3101], 'interference': [2837], 'lateral': [2843], 'diffusion': [2844], 'proton-phosphorus': [2851], 'MAS.': [2854], 'Such': [2855, 5320], 'may': [2857, 3672, 4726, 4918, 4974, 5120, 5323, 5467], 'inefficient': [2860], 'incomplete': [2864], 'averaging': [2865, 4019], 'under': [2870], 'Ref.': [2877], '21Traikia': [2878], 'Langlais': [2880], 'D.B.': [2881], 'Cannarozzi': [2882], 'G.M.': [2883], 'Devaux': [2884], 'P.F.': [2885], '125:': [2890], '140-144Crossref': [2891], '(18)': [2894], 'Scholar': [2896], 'discussion).': [2898], 'composition': [2912], 'strong': [2915], 'approximately': [2918, 2959, 3013], '−1.0': [2919, 2960, 2978, 3103, 3286], 'attributed': [2921], 'weak': [2928], '0.1': [2931, 3083], '(spectrum': [2935], 'not': [2936, 3042, 3107, 3121, 3184, 4473, 4597, 5121, 5294], 'shown).': [2937], 'distinctive': [2950], 'resonances,': [2951, 3009], '4,': [2953, 4695], 'one': [2957, 3010, 3399], 'dependent': [2969], '(TableI).': [2974], 'FWHH': [3012, 3025, 4698], 'equal': [3014], '1.61': [3016], 'another': [3019], '0.35': [3021], 'FWHH.': [3023], 'higher': [3032], 'concentration,': [3034], 'whereas': [3035], 'narrower': [3039], 'does': [3041, 3106], 'clear': [3045], 'dependence': [3046], 'resonance,': [3052], 'probably': [3054], 'pores': [3068, 3482, 4471, 4904, 4952, 4969], 'EM': [3070, 4047, 4121], 'evidence': [3071], 'below)': [3072], 'partially': [3075], 'fused': [3076], 'liposomes.': [3077], 'low': [3079], 'depend': [3108], 'concentration.Table': [3111], 'IPhosphorous-31': [3112], 'shiftsPneumolysinςpaBilayer': [3115], 'bilayers.ςfI': [3125], 'pI': [3126], 'fmol': [3127], '%ppmppm%%0.000.000.0001000.500.65−1.0432681.251.01−1.0540601.501.12−1.056040Phosphorous-31': [3128], '(ςp,': [3132, 3199], 'ςf)': [3133, 3200], 'non-bilayer': [3139, 3206], 'total': [3141, 3154, 3208, 3221, 3280, 4314, 4377], 'I': [3148, 3215, 4346], 'fraction': [3151, 3218, 3956, 4311, 4881], 'shown.1-a': [3177], 'Bilayer': [3178], 'Open': [3189], 'table': [3190], 'new': [3193], 'tab': [3194], 'Phosphorous-31': [3195], 'shown.': [3244], 'b)': [3251], 'pronounced': [3254], 'ς,': [3263], '(Table': [3268, 3295, 4307], 'I).': [3269, 3296], 'increased': [3294], 'concentration-dependent': [3299], 'parallels,': [3307], 'qualitative': [3310], 'way,': [3311], 'reverse': [3319], 'pattern,': [3321], 'Therefore,': [3330], 'associated': [3339, 3657, 3705, 4330, 4394, 4475, 5160, 5463], 'information': [3353], 'topology': [3358], 'micrographs': [3369, 3387, 3982, 4755], '1.25': [3378], 'vesicles,': [3391], 'varying': [3395], 'hundred': [3400, 3404], 'few': [3403, 3415], 'nanometers.': [3405], 'Fractures': [3406], 'across': [3407], 'reveal': [3410, 3438, 4771], 'only': [3413, 3547, 5122], 'thus': [3418], 'multibilayer': [3422], 'structures.': [3423, 3681, 3711, 3753], 'Nonaggregated': [3424], 'seen': [3428, 3562, 4118], 'aggregates.': [3434], 'Multifaceted': [3435], 'surfaces': [3437, 3443], 'close': [3439], 'foam-like': [3440], 'some': [3445], 'circular': [3451, 3473], '∼25': [3454, 3527], 'internal': [3456, 4031], 'diameter': [3457, 3525, 3532, 3943, 4032], 'a,': [3460, 3539, 3622], 'arrow': [3461, 3540], 'p).': [3462], 'Previously': [3463], 'represent,': [3476], 'likely,': [3478], 'membrane-incorporated': [3479], 'Free': [3513], 'unassociated': [3516], 'inside': [3524], 'outside': [3531], 'r).': [3541], 'appear': [3543, 4795], 'solution': [3571, 4231, 5258], '(arrow)': [3605], '(∼25-nm': [3613], 'inner': [3614], 'localized': [3623], 'boundary': [3626], 'having': [3630], 'common': [3632], 'wall.': [3633], 'play': [3639], 'role': [3641], 'fusion.': [3646], 'resembling': [3650], 'proteolipid': [3654, 3680, 4666], 'ring': [3661, 3977, 4010, 4142], 'b.': [3666], 'An': [3682], 'important': [3683, 4465, 5154], 'aspect': [3684], 'destabilizing': [3694], 'withdrawal': [3706], 'phospholipids': [3708, 3725, 4498], 'b–d)': [3719], 'originate': [3720], 'corresponding': [3733], 'slowly': [3738], "MLV's,": [3740], 'together': [3741], 'powder,': [3761], 'edge': [3768], 'located': [3769], '0°': [3775], 'extreme,': [3776], 'indicative': [3778], 'axis': [3785, 3794, 4016], 'averaging,': [3789], 'perpendicular': [3790], 'main': [3793], 'rotation.': [3797, 4029], 'situation': [3799], 'observed,': [3801], '(15Yeagle': [3812], '22Bloom': [3822], 'Thewalt': [3824], 'Membr.': [3827], '1995;': [3829], '12:': [3830], '9-13Crossref': [3831], '(37)': [3834], 'inversion': [3841], 'distribution,': [3845], 'overall': [3847], 'pneumolysin-induced': [3900, 4835], '(∼10': [3903], '∼one-fourth': [3909], 'ppm).': [3920], 'axial': [3927, 4028], 'they': [3937, 4467, 4492, 4843, 4902], 'smaller': [3939], 'aggregate': [3947], 'HII': [3950], 'phase.': [3951], 'strongly': [3965], 'structures,': [3978, 4804], 'possess': [3986], 'necessary': [3990], 'give': [3992], 'component': [3998], 'b–d.': [4008], 'Their': [4009], 'shape': [4011], 'preferred': [4015], 'facilitate': [4026], 'negative': [4045], 'staining': [4046], '17Gilbert': [4080, 5397], 'explanation': [4114], 'detected': [4123], '2)': [4137], 'annulus': [4146], 'decorating': [4147], 'exterior': [4149], 'oligomer': [4152], '(Fig.6).': [4153], 'interior': [4155], 'could': [4159], 'filled': [4161], 'empty,': [4165], 'forms': [4168], '2R.': [4206], 'C.': [4208, 4929, 4992, 5496, 5547], 'Gilbert,': [4209], 'L.': [4211, 5486, 5537], 'Jimenez,': [4212], 'Chen,': [4214], 'H.': [4216], 'R.': [4217, 4990, 5490, 5492, 5541, 5543], 'Saibil,': [4218], 'unpublished': [4219], 'results.': [4220], 'case': [4223], 'evolution': [4225], 'destruction': [4243], 'membrane.': [4246], 'comparison': [4257], 'intensities': [4260], 'wide': [4264], 'patterns.': [4269], 'concomitant': [4271], 'measure': [4291], '(proteolipid': [4299], 'rings).': [4300], 'Thus': [4301], 'quantitation': [4303], 'I)': [4308], 'reflects': [4309], 'lipid,': [4315], 'segregated': [4316], 'proportion': [4325, 5142], 'detached': [4334], 'particular,': [4340], 'values': [4342], 'Table': [4345], '1.5': [4361], '32': [4372], '60%': [4374], 'content.': [4379], 'Consequently,': [4380], '∼1': [4385], 'pneumolysin,': [4389, 5193, 5327], '28': [4390], 'monomer': [4398], 'number': [4401, 4892], 'per': [4405], 'oligomer,': [4406], 'vary': [4448], '840': [4450], '1400,': [4452], 'respectively.': [4453], 'gained': [4456], 'fundamentally': [4464], 'suggest': [4468, 4593, 4854, 5117], 'do': [4472, 4953], 'fragments': [4481], 'cells,': [4484], 'lysed.': [4488], 'contrary,': [4491], 'become': [4493], 'dispersed': [4494], 'possibly': [4500], 'However,': [4503], 'interpreted': [4512], 'premise': [4515], 'following': [4525], 'exist': [4528, 4630], 'part': [4534], 'permeabilized': [4536], '5Shatursky': [4563], 'Our': [4591], 'valid': [4599], 'assumption': [4600], 'make': [4602], 'therefore': [4605], 'conclusions': [4606], 'regions': [4609], 'interact': [4613], 'cannot': [4616], 'simply': [4617], 'based': [4619], 'data,': [4622], 'apparently': [4629], 'where': [4636], 'solid': [4637], 'distinguish': [4644], 'quantitate': [4646], 'approximate': [4649], 'way.': [4650], 'possible': [4653], 'limit': [4658], 'life-time': [4661], 'existence': [4664, 5250], 'distinct': [4682], 'populations,': [4684], 'CS': [4689], 'separation': [4690], '∼2': [4692], 'TableI).': [4696], '∼0.3': [4707], 'any': [4712], 'putative': [4713], 'occur': [4727, 5325], 'slower': [4732], '60': [4734], '(∼1.7': [4736], 'MHz)': [4740], 'stable': [4746], 'over': [4747], 'pneumolysin-containing': [4757], 'systems': [4759], '(∼104': [4767], 'degrees/second)': [4768], 'initial': [4781], 'suspension,': [4782], 'toxin-independent': [4786], 'fashion': [4787], 'remaining': [4790], 'lipid.': [4791], 'immediate': [4798], 'vicinity': [4799], 'trapped': [4805], 'larger': [4807], 'aggregates,': [4809], 'indicating': [4810], 'coexist': [4815], 'liposome-containing': [4821], 'toxin.': [4822, 5319], 'Bearing': [4823], 'mind': [4825], 'location': [4828], 'aggregate,': [4836, 5133], 'reasonable': [4839], 'deduce': [4841], 'firstly': [4861], 'oligomerization': [4863, 5057], 'but': [4869, 5045, 5126], 'later': [4871], 'enter': [4875], 'solution,': [4877], 'withdrawing': [4878], '6).': [4890], 'conductance': [4894], 'create': [4903], 'range': [4907], 'sizes': [4909], 'lifetimes': [4911], 'smallest': [4915], 'blocked': [4920], 'divalent': [4922], 'cations': [4923], '(24Korchev': [4924], 'Y.E.': [4925], 'Bashford': [4926], 'C.L.': [4927], 'Pederzolli': [4928], 'Pasternak': [4930], 'C.A.': [4931], '329:': [4941], '571-577Crossref': [4942], '(82)': [4945], 'observation': [4949], 'indeed': [4954], 'What': [4958], 'our': [4959, 5070], 'precise': [4965], 'nature': [4966], 'still': [4971], 'uncertain,': [4972], 'involve': [4975], 'lesions': [4976], 'formed': [4977], 'interfaces': [4980], 'nascent': [4982], '(25Palmer': [4987], 'Harris': [4989], 'Freytag': [4991], 'Kehoe': [4993], 'Tranum-Jensen': [4995, 5279], 'Bhakdi': [4997], 'EMBO': [4999], '17:': [5002], '1598-1605Crossref': [5003], '(156)': [5006], 'discrete': [5010], 'holes': [5048], 'alone.': [5052], 'Furthermore,': [5053], 'effects': [5054], 'downstream': [5055], 'pore-formation': [5059], 'scale': [5062], 'redistribution': [5063], 'indicated': [5068], 'data.': [5071], 'suggested': [5074], 'lytic': [5077], 'membrane,': [5093], 'observations': [5116], 'permeabilize': [5123], 'them': [5129], 'bleb,': [5131], 'fuse.': [5136], 'appearance': [5138], 'oligomer-lipid': [5150], 'understanding': [5156], 'noncytolytic': [5158], 'mentioned': [5164], 'above,': [5165], 'ability': [5169], 'directly': [5170], 'activate': [5172, 5269], 'manner.': [5179], 'occurs': [5181], 'classical': [5184], 'pathway': [5185], 'IgG-Fc,': [5194, 5345], 'Toxin': [5218], 'capable': [5224], 'numbers': [5253], 'might': [5259], 'explain': [5260], 'facility.': [5262], 'Although': [5263], 'reported': [5267], 'anti-streptolysin': [5275], 'antibodies': [5276], '(26Bhakdi': [5277], 'Infect.': [5281], 'Immun.': [5282], '1985;': [5283], '48:': [5284], '713-719Crossref': [5285], 'demonstrated': [5296], 'so': [5297], 'far': [5298], 'CBTs.': [5301], 'found': [5308], 'hyperactivating': [5312, 5432], 'phenomenon': [5322], 'C-terminal': [5337], 'domain)': [5338], 'fold': [5341], '2Rossjohn': [5373], 'IgG': [5428], 'itself': [5429], 'oligomerized': [5437], '(27Wright': [5438], 'J.K.': [5439], 'Tschopp': [5440], 'Jaton': [5442], 'J.-T.': [5443], 'Engel': [5444], '187:': [5449], '775-780Crossref': [5450], '(49)': [5453], 'themselves': [5468], 'elicit': [5469], 'immune': [5471], '(nonplanar)': [5475], 'highly': [5483], 'immunogenic': [5484], '(28Aguillar': [5485, 5536], 'Ortega-Pierres': [5487, 5538], 'G.': [5488, 5539], 'Campos': [5489, 5540], 'Fonseca': [5491, 5542], 'Ibánez': [5493, 5544], 'Wong': [5495, 5546], 'Farfán': [5497, 5548], 'Naciff': [5499, 5550], 'J.M': [5500, 5551], 'Kaetzel': [5501, 5552], 'Dedman': [5503, 5554], 'J.R.': [5504, 5555], 'Baeza': [5505, 5556], 'Chem.': [5509, 5560], '274:': [5511, 5562], '25193-25196Abstract': [5512, 5563], '(34)': [5520, 5571], 'immunogenicity': [5524], 'thought': [5529], 'high': [5534], 'curvature': [5535], 'We': [5574], 'like': [5576], 'thank': [5578], 'David': [5579], 'his': [5582], 'advice': [5583], 'EM.': [5586]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2108882816', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 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