Publication Information

{'id': 'https://openalex.org/W3035528006', 'doi': 'https://doi.org/10.1155/2020/8537026', 'title': 'Cortex <i>Cercis chinensis</i> Granules Attenuate <i>Streptococcus pneumoniae</i> Virulence by Targeting Pneumolysin', 'display_name': 'Cortex <i>Cercis chinensis</i> Granules Attenuate <i>Streptococcus pneumoniae</i> Virulence by Targeting Pneumolysin', 'publication_year': 2020, 'publication_date': '2020-01-01', 'ids': {'openalex': 'https://openalex.org/W3035528006', 'doi': 'https://doi.org/10.1155/2020/8537026', 'mag': '3035528006', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32617112', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7315261'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2020/8537026', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2020/8537026.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://downloads.hindawi.com/journals/ecam/2020/8537026.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079758523', 'display_name': 'Yan Xu', 'orcid': 'https://orcid.org/0000-0003-2697-1297'}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Xu', 'raw_affiliation_strings': ['Changchun University of Chinese Medicine, Changchun, Jilin 130117, China'], 'affiliations': [{'raw_affiliation_string': 'Changchun University of Chinese Medicine, Changchun, Jilin 130117, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100452577', 'display_name': 'Yanbo Wang', 'orcid': 'https://orcid.org/0000-0002-1249-0444'}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanbo Wang', 'raw_affiliation_strings': ['Changchun University of Chinese Medicine, Changchun, Jilin 130117, China'], 'affiliations': [{'raw_affiliation_string': 'Changchun University of Chinese Medicine, Changchun, Jilin 130117, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108744719', 'display_name': 'Yinan Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yinan Guo', 'raw_affiliation_strings': ['Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101444267', 'display_name': 'Lina Wei', 'orcid': 'https://orcid.org/0000-0002-3816-898X'}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lina Wei', 'raw_affiliation_strings': ['Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037227889', 'display_name': 'Lizhong Ding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lizhong Ding', 'raw_affiliation_strings': ['Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115598407', 'display_name': 'Zhongtian Wang', 'orcid': 'https://orcid.org/0000-0003-3417-9865'}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhongtian Wang', 'raw_affiliation_strings': ['Changchun University of Chinese Medicine, Changchun, Jilin 130117, China'], 'affiliations': [{'raw_affiliation_string': 'Changchun University of Chinese Medicine, Changchun, Jilin 130117, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010236776', 'display_name': 'Liping Sun', 'orcid': 'https://orcid.org/0000-0002-3679-4469'}, 'institutions': [{'id': 'https://openalex.org/I4210128075', 'display_name': 'Changchun University of Chinese Medicine', 'ror': 'https://ror.org/035cyhw15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210128075']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liping Sun', 'raw_affiliation_strings': ['Changchun University of Chinese Medicine, Changchun, Jilin 130117, China'], 'affiliations': [{'raw_affiliation_string': 'Changchun University of Chinese Medicine, Changchun, Jilin 130117, China', 'institution_ids': ['https://openalex.org/I4210128075']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5010236776'], 'corresponding_institution_ids': ['https://openalex.org/I4210128075'], 'apc_list': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'fwci': 0.16, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.60355, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 74}, 'biblio': {'volume': '2020', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10654', 'display_name': 'Pneumonia and Respiratory Infections', 'score': 0.979, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10654', 'display_name': 'Pneumonia and Respiratory Infections', 'score': 0.979, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 0.979, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9768, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pneumolysin', 'display_name': 'Pneumolysin', 'score': 0.9883752}], 'concepts': [{'id': 'https://openalex.org/C2776088486', 'wikidata': 'https://www.wikidata.org/wiki/Q7205996', 'display_name': 'Pneumolysin', 'level': 4, 'score': 0.9883752}, {'id': 'https://openalex.org/C2781253189', 'wikidata': 'https://www.wikidata.org/wiki/Q221179', 'display_name': 'Streptococcus pneumoniae', 'level': 3, 'score': 0.8353367}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.7405119}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.6750577}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39618954}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29891032}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16565007}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.108964115}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2020/8537026', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2020/8537026.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/d8a6b88c5854496ca66635a320213102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7315261', 'pdf_url': 'https://europepmc.org/articles/pmc7315261?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32617112', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2020/8537026', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2020/8537026.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.69, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2018J106'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2019023'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2017YFC1703202'}], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1502143437', 'https://openalex.org/W2029248129', 'https://openalex.org/W2038062994', 'https://openalex.org/W2053220097', 'https://openalex.org/W2076893605', 'https://openalex.org/W2093327342', 'https://openalex.org/W2101262154', 'https://openalex.org/W2115386681', 'https://openalex.org/W2123109660', 'https://openalex.org/W2137536958', 'https://openalex.org/W2143391838', 'https://openalex.org/W2159726435', 'https://openalex.org/W2171327947', 'https://openalex.org/W2186644145', 'https://openalex.org/W2195753589', 'https://openalex.org/W2303735907', 'https://openalex.org/W2500727927', 'https://openalex.org/W2525759404', 'https://openalex.org/W2541093824', 'https://openalex.org/W2567336791', 'https://openalex.org/W2606895009', 'https://openalex.org/W2608595508', 'https://openalex.org/W2800561326'], 'related_works': ['https://openalex.org/W4394577897', 'https://openalex.org/W4237788997', 'https://openalex.org/W4221125579', 'https://openalex.org/W3035528006', 'https://openalex.org/W3031860666', 'https://openalex.org/W2525759404', 'https://openalex.org/W2384025977', 'https://openalex.org/W2012607141', 'https://openalex.org/W1976925323', 'https://openalex.org/W1589985420'], 'abstract_inverted_index': {'Pore-forming': [0], 'toxins': [1], 'produced': [2], 'by': [3, 23], 'bacteria': [4], 'are': [5], 'some': [6], 'of': [7, 39, 80, 97, 107, 118, 126, 135], 'the': [8, 34, 43, 71, 77, 105, 116, 124, 130, 133, 140], 'most': [9], 'important': [10], 'molecular': [11], 'weapons': [12], 'for': [13, 52, 168, 177], 'bacterial': [14], 'virulence.': [15], 'Pneumolysin': [16], '(PLY)': [17], 'is': [18, 48], 'a': [19, 30, 49, 67, 149, 165, 174], 'pore-forming': [20, 78], 'toxin': [21], 'secreted': [22], 'Streptococcus': [24], 'pneumoniae': [25, 57, 160, 171], '(S.': [26], 'pneumoniae)': [27], 'and': [28, 37, 82, 88, 132, 137, 156, 173], 'plays': [29], 'vital': [31], 'role': [32], 'in': [33, 42, 139], 'spread,': [35], 'colonization,': [36], 'invasion': [38], 'this': [40, 60], 'bacterium': [41], 'host,': [44], 'indicating': [45], 'that': [46, 112, 147], 'PLY': [47, 81, 98, 154], 'promising': [50], 'target': [51], 'developing': [53], 'treatments': [54], 'against': [55, 84], 'S.': [56, 122, 159, 170], 'infection.': [58], 'In': [59, 100, 142], 'study,': [61], 'Cortex': [62], 'Cercis': [63], 'chinensis': [64], 'granules': [65], '(CCCGs),': [66], 'prescription': [68], 'drug': [69], 'on': [70], 'market,': [72], 'were': [73], 'shown': [74], 'to': [75, 129], 'inhibit': [76, 153], 'activity': [79, 94, 155], 'protect': [83], 'PLY-mediated': [85], 'cell': [86, 90], 'hemolysis': [87], 'A549': [89], 'death': [91, 117], 'without': [92], 'antibacterial': [93], 'or': [95], 'inhibition': [96], 'production.': [99], 'addition,': [101], 'CCCG': [102], 'treatment': [103], 'inhibited': [104], 'oligomerization': [106], 'PLY.': [108], 'Animal': [109], 'experiments': [110], 'showed': [111], 'CCCGs': [113], 'can': [114], 'reduce': [115], 'mice': [119], 'infected': [120], 'with': [121], 'pneumoniae,': [123], 'degree': [125], 'pathological': [127], 'damage': [128], 'lungs,': [131], 'levels': [134], 'TNF-α': [136], 'IL-6': [138], 'lungs.': [141], 'summary,': [143], 'our': [144], 'results': [145], 'demonstrated': [146], 'CCCGs,': [148], 'marketed': [150], 'Chinese': [151], 'medicine,': [152], 'subsequently': [157], 'attenuate': [158], 'virulence,': [161], 'which': [162], 'would': [163], 'offer': [164], 'novel': [166], 'strategy': [167], 'fighting': [169], 'infection': [172], 'new': [175], 'use': [176], 'CCCGs.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3035528006', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-24T07:08:15.821197', 'created_date': '2020-06-19'}