Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2096662626', 'doi': 'https://doi.org/10.1128/jcm.42.9.4355-4357.2004', 'title': 'Pneumolysin Is a Key Factor in Misidentification of Macrolide-Resistant <i>Streptococcus pneumoniae</i> and Is a Putative Virulence Factor of <i>S. mitis</i> and Other Streptococci', 'display_name': 'Pneumolysin Is a Key Factor in Misidentification of Macrolide-Resistant <i>Streptococcus pneumoniae</i> and Is a Putative Virulence Factor of <i>S. mitis</i> and Other Streptococci', 'publication_year': 2004, 'publication_date': '2004-09-01', 'ids': {'openalex': 'https://openalex.org/W2096662626', 'doi': 'https://doi.org/10.1128/jcm.42.9.4355-4357.2004', 'mag': '2096662626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15365043', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/516304'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jcm.42.9.4355-4357.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53087977', 'display_name': 'Journal of Clinical Microbiology', 'issn_l': '0095-1137', 'issn': ['0095-1137', '1070-633X', '1098-660X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc516304?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079474417', 'display_name': 'C. Neeleman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Chris Neeleman', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, University Hospital St. Radboud'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, University Hospital St. Radboud', 'institution_ids': ['https://openalex.org/I145872427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030682355', 'display_name': 'Corné H. W. Klaassen', 'orcid': 'https://orcid.org/0000-0002-3439-0903'}, 'institutions': [{'id': 'https://openalex.org/I4210113935', 'display_name': 'Canisius-Wilhelmina Ziekenhuis', 'ror': 'https://ror.org/027vts844', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113935']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Corné H. W. Klaassen', 'raw_affiliation_strings': ['Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I4210113935']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018316725', 'display_name': 'Debbie M. Klomberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113935', 'display_name': 'Canisius-Wilhelmina Ziekenhuis', 'ror': 'https://ror.org/027vts844', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113935']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Debbie M. Klomberg', 'raw_affiliation_strings': ['Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I4210113935']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109212665', 'display_name': 'Hanneke A. de Valk', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113935', 'display_name': 'Canisius-Wilhelmina Ziekenhuis', 'ror': 'https://ror.org/027vts844', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113935']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hanneke A. de Valk', 'raw_affiliation_strings': ['Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I4210113935']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002934725', 'display_name': 'Johan W. Mouton', 'orcid': 'https://orcid.org/0000-0001-6736-4149'}, 'institutions': [{'id': 'https://openalex.org/I4210113935', 'display_name': 'Canisius-Wilhelmina Ziekenhuis', 'ror': 'https://ror.org/027vts844', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113935']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Johan W. Mouton', 'raw_affiliation_strings': ['Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology and Infectious Diseases, Canisius/Wilhelmina Hospital, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I4210113935']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.386, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.868964, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '42', 'issue': '9', 'first_page': '4355', 'last_page': '4357'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10654', 'display_name': 'Pneumonia and Respiratory Infections', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pneumolysin', 'display_name': 'Pneumolysin', 'score': 0.99723816}, {'id': 'https://openalex.org/keywords/streptococcus-mitis', 'display_name': 'Streptococcus mitis', 'score': 0.884792}, {'id': 'https://openalex.org/keywords/virulence-factor', 'display_name': 'Virulence factor', 'score': 0.6661637}], 'concepts': [{'id': 'https://openalex.org/C2776088486', 'wikidata': 'https://www.wikidata.org/wiki/Q7205996', 'display_name': 'Pneumolysin', 'level': 4, 'score': 0.99723816}, {'id': 'https://openalex.org/C2781253189', 'wikidata': 'https://www.wikidata.org/wiki/Q221179', 'display_name': 'Streptococcus pneumoniae', 'level': 3, 'score': 0.9138918}, {'id': 'https://openalex.org/C2777480049', 'wikidata': 'https://www.wikidata.org/wiki/Q684674', 'display_name': 'Streptococcus mitis', 'level': 4, 'score': 0.884792}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.83805275}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7004073}, {'id': 'https://openalex.org/C2781090273', 'wikidata': 'https://www.wikidata.org/wiki/Q1623405', 'display_name': 'Virulence factor', 'level': 4, 'score': 0.6661637}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.5709568}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4891234}, {'id': 'https://openalex.org/C2778663903', 'wikidata': 'https://www.wikidata.org/wiki/Q140018', 'display_name': 'Streptococcaceae', 'level': 3, 'score': 0.45687333}, {'id': 'https://openalex.org/C42062724', 'wikidata': 'https://www.wikidata.org/wiki/Q1209205', 'display_name': '16S ribosomal RNA', 'level': 3, 'score': 0.41263485}, {'id': 'https://openalex.org/C2778276568', 'wikidata': 'https://www.wikidata.org/wiki/Q190161', 'display_name': 'Streptococcus', 'level': 3, 'score': 0.40956807}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.28369337}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.26480073}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.06637162}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013291', 'descriptor_name': 'Streptococcus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013301', 'descriptor_name': 'Streptolysins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012336', 'descriptor_name': 'RNA, Ribosomal, 16S', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012336', 'descriptor_name': 'RNA, Ribosomal, 16S', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013291', 'descriptor_name': 'Streptococcus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013291', 'descriptor_name': 'Streptococcus', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013301', 'descriptor_name': 'Streptolysins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jcm.42.9.4355-4357.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53087977', 'display_name': 'Journal of Clinical Microbiology', 'issn_l': '0095-1137', 'issn': ['0095-1137', '1070-633X', '1098-660X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc516304', 'pdf_url': 'https://europepmc.org/articles/pmc516304?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516304', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15365043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc516304', 'pdf_url': 'https://europepmc.org/articles/pmc516304?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.5, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1589985420', 'https://openalex.org/W1975688942', 'https://openalex.org/W1982058698', 'https://openalex.org/W1983796656', 'https://openalex.org/W2043019909', 'https://openalex.org/W2064505667', 'https://openalex.org/W2068101456', 'https://openalex.org/W2081783368', 'https://openalex.org/W2116734194', 'https://openalex.org/W2117834016', 'https://openalex.org/W2127310017', 'https://openalex.org/W2158714788', 'https://openalex.org/W2159323999', 'https://openalex.org/W2159427865', 'https://openalex.org/W2170118212', 'https://openalex.org/W2172154969', 'https://openalex.org/W2409986902'], 'related_works': ['https://openalex.org/W4367595191', 'https://openalex.org/W4236642447', 'https://openalex.org/W2142209816', 'https://openalex.org/W2141992911', 'https://openalex.org/W2096662626', 'https://openalex.org/W2084807013', 'https://openalex.org/W1979507684', 'https://openalex.org/W1935090476', 'https://openalex.org/W1671726211', 'https://openalex.org/W1584241653'], 'abstract_inverted_index': {'We': [0], 'evaluated': [1], 'the': [2, 10, 32, 35, 49], 'applicability': [3], 'of': [4, 9, 12, 48], 'ply': [5, 36, 50], 'PCR': [6], 'for': [7, 43], 'confirmation': [8], 'identification': [11], 'Streptococcus': [13, 57], 'pneumoniae.': [14, 45], 'lytA': [15, 33], 'PCR,': [16], '16S': [17], 'rRNA': [18], 'sequencing,': [19], 'and': [20], 'amplified-fragment': [21], 'length': [22], 'polymorphism': [23], 'were': [24], 'used': [25], 'as': [26], 'reference': [27], 'methods.': [28], 'In': [29], 'contrast': [30], 'to': [31, 39], 'gene,': [34], 'gene': [37, 51], 'proved': [38], 'be': [40], 'not': [41], 'specific': [42], 'S.': [44], 'The': [46], 'presence': [47], 'in': [52, 55], 'other': [53], 'streptococci,': [54], 'particular': [56], 'mitis,': [58], 'suggests': [59], 'that': [60], 'pneumolysin': [61], 'plays': [62], 'a': [63], 'pathogenic': [64], 'role.': [65]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2096662626', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T04:51:27.506319', 'created_date': '2016-06-24'}