Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2105501464', 'doi': 'https://doi.org/10.1107/s0108270102016463', 'title': '<i>N</i>-<i>tert</i>-Butyl-<i>N</i>′-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition', 'display_name': '<i>N</i>-<i>tert</i>-Butyl-<i>N</i>′-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition', 'publication_year': 2002, 'publication_date': '2002-09-30', 'ids': {'openalex': 'https://openalex.org/W2105501464', 'doi': 'https://doi.org/10.1107/s0108270102016463', 'mag': '2105501464', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12359948'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1107/s0108270102016463', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149116045', 'display_name': 'Acta Crystallographica Section C Crystal Structure Communications', 'issn_l': '0108-2701', 'issn': ['0108-2701', '1600-5759'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004240078', 'display_name': 'Catherine Michaux', 'orcid': 'https://orcid.org/0000-0001-8208-3310'}, 'institutions': [{'id': 'https://openalex.org/I149768937', 'display_name': 'University of Namur', 'ror': 'https://ror.org/03d1maw17', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149768937']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Catherine Michaux', 'raw_affiliation_strings': ['Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium', 'institution_ids': ['https://openalex.org/I149768937']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041424887', 'display_name': 'Jean‐Michel Dogné', 'orcid': 'https://orcid.org/0000-0003-2107-1804'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jean-Michel Dogné', 'raw_affiliation_strings': ["Laboratoire de Chimie Pharmaceutique, Centre Interfacultaire de Recherche en Pharmacochimie des Substances Naturelles et Synthétiques, Université de Liège, 1 Avenue de l'Hôpital, B-4000 Liège, Belgium"], 'affiliations': [{'raw_affiliation_string': "Laboratoire de Chimie Pharmaceutique, Centre Interfacultaire de Recherche en Pharmacochimie des Substances Naturelles et Synthétiques, Université de Liège, 1 Avenue de l'Hôpital, B-4000 Liège, Belgium", 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017654335', 'display_name': 'Bernadette Norberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149768937', 'display_name': 'University of Namur', 'ror': 'https://ror.org/03d1maw17', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149768937']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bernadette Norberg', 'raw_affiliation_strings': ['Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium', 'institution_ids': ['https://openalex.org/I149768937']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074836866', 'display_name': 'François Durant', 'orcid': 'https://orcid.org/0000-0002-4737-1189'}, 'institutions': [{'id': 'https://openalex.org/I149768937', 'display_name': 'University of Namur', 'ror': 'https://ror.org/03d1maw17', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149768937']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'François Durant', 'raw_affiliation_strings': ['Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium', 'institution_ids': ['https://openalex.org/I149768937']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081430054', 'display_name': 'Bernard Masereel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149768937', 'display_name': 'University of Namur', 'ror': 'https://ror.org/03d1maw17', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149768937']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bernard Masereel', 'raw_affiliation_strings': ['Département de Pharmacie, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Département de Pharmacie, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium', 'institution_ids': ['https://openalex.org/I149768937']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3760, 'currency': 'USD', 'value_usd': 3760, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.463, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.355355, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 69}, 'biblio': {'volume': '58', 'issue': '10', 'first_page': 'o621', 'last_page': 'o623'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10464', 'display_name': 'Chemical Crystallography', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10464', 'display_name': 'Chemical Crystallography', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10274', 'display_name': 'Heterocyclic Compounds for Drug Discovery', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thromboxane-receptor', 'display_name': 'Thromboxane receptor', 'score': 0.9179764}, {'id': 'https://openalex.org/keywords/thromboxane-a-synthase', 'display_name': 'Thromboxane-A synthase', 'score': 0.8239083}, {'id': 'https://openalex.org/keywords/tubulin-inhibitors', 'display_name': 'Tubulin Inhibitors', 'score': 0.435652}], 'concepts': [{'id': 'https://openalex.org/C51603380', 'wikidata': 'https://www.wikidata.org/wiki/Q411978', 'display_name': 'Thromboxane receptor', 'level': 4, 'score': 0.9179764}, {'id': 'https://openalex.org/C173202427', 'wikidata': 'https://www.wikidata.org/wiki/Q408575', 'display_name': 'Thromboxane-A synthase', 'level': 4, 'score': 0.8239083}, {'id': 'https://openalex.org/C2777383412', 'wikidata': 'https://www.wikidata.org/wiki/Q4770891', 'display_name': 'Antagonism', 'level': 3, 'score': 0.74806356}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.6411529}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.623693}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.512293}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.4546956}, {'id': 'https://openalex.org/C2778122271', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Receptor antagonist', 'level': 4, 'score': 0.41862032}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3835042}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.36186078}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2631768}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21891013}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17889407}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.14924332}], 'mesh': [{'descriptor_ui': 'D017482', 'descriptor_name': 'Receptors, Thromboxane', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013453', 'descriptor_name': 'Sulfonylurea Compounds', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D013453', 'descriptor_name': 'Sulfonylurea Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008968', 'descriptor_name': 'Molecular Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017482', 'descriptor_name': 'Receptors, Thromboxane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013453', 'descriptor_name': 'Sulfonylurea Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1107/s0108270102016463', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149116045', 'display_name': 'Acta Crystallographica Section C Crystal Structure Communications', 'issn_l': '0108-2701', 'issn': ['0108-2701', '1600-5759'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12359948', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.47, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': ['https://openalex.org/W4397077620'], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W1969635440', 'https://openalex.org/W2006840712', 'https://openalex.org/W2050521778', 'https://openalex.org/W2079362203', 'https://openalex.org/W2082182928'], 'related_works': ['https://openalex.org/W327792311', 'https://openalex.org/W2399782909', 'https://openalex.org/W2312229444', 'https://openalex.org/W2108301756', 'https://openalex.org/W2056031692', 'https://openalex.org/W2047854358', 'https://openalex.org/W2029344288', 'https://openalex.org/W2010146877', 'https://openalex.org/W1967177765', 'https://openalex.org/W1541108101'], 'abstract_inverted_index': {'The': [0], 'title': [1], 'compound': [2], '(BM531),': [3], 'C17H26N4O5S,': [4], 'has': [5], 'been': [6], 'designed': [7], 'for': [8], 'use': [9], 'as': [10], 'both': [11], 'a': [12, 18], 'thromboxane': [13, 19], 'synthase': [14], 'inhibitor': [15], '(TXSI)': [16], 'and': [17], 'receptor': [20], 'antagonist': [21], '(TXRA).': [22], 'We': [23], 'report': [24], 'here': [25], 'the': [26, 32], 'X-ray': [27], 'crystal': [28], 'structure': [29], 'determination': [30], 'of': [31], 'compound.': [33]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2105501464', 'counts_by_year': [], 'updated_date': '2024-09-14T10:20:22.047735', 'created_date': '2016-06-24'}