Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2108301756', 'doi': 'https://doi.org/10.2174/0929867043365260', 'title': 'New Developments on Thromboxane and Prostacyclin Modulators Part I: Thromboxane Modulators', 'display_name': 'New Developments on Thromboxane and Prostacyclin Modulators Part I: Thromboxane Modulators', 'publication_year': 2004, 'publication_date': '2004-05-01', 'ids': {'openalex': 'https://openalex.org/W2108301756', 'doi': 'https://doi.org/10.2174/0929867043365260', 'mag': '2108301756', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15134516'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/0929867043365260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041424887', 'display_name': 'Jean‐Michel Dogné', 'orcid': 'https://orcid.org/0000-0003-2107-1804'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jean-Michel Dogne', 'raw_affiliation_strings': ["Natural and Synthetic Drug Research Center, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium."], 'affiliations': [{'raw_affiliation_string': "Natural and Synthetic Drug Research Center, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium.", 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087042354', 'display_name': 'Xavier de Leval', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xavier Leval', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082090154', 'display_name': 'Julien Hanson', 'orcid': 'https://orcid.org/0000-0001-7063-7590'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Julien Hanson', 'raw_affiliation_strings': ['Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >'], 'affiliations': [{'raw_affiliation_string': 'Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >', 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057159714', 'display_name': 'Michel Frédérich', 'orcid': 'https://orcid.org/0000-0002-0770-9990'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Michel Frederich', 'raw_affiliation_strings': ['Université de Liège - ULiege > Département de pharmacie > Pharmacognosie >'], 'affiliations': [{'raw_affiliation_string': 'Université de Liège - ULiege > Département de pharmacie > Pharmacognosie >', 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070075671', 'display_name': 'Bernard Lambermont', 'orcid': 'https://orcid.org/0000-0001-7915-8748'}, 'institutions': [{'id': 'https://openalex.org/I4210134544', 'display_name': 'Centre Hospitalier Universitaire de Liège', 'ror': 'https://ror.org/044s61914', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134544']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bernard Lambermont', 'raw_affiliation_strings': ['Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants >'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants >', 'institution_ids': ['https://openalex.org/I4210134544']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084045526', 'display_name': 'Alexandre Ghuysen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Ghuysen', 'raw_affiliation_strings': ['Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]'], 'affiliations': [{'raw_affiliation_string': 'Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]', 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088994269', 'display_name': 'Angela Casini', 'orcid': 'https://orcid.org/0000-0003-1599-9542'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Angela Casini', 'raw_affiliation_strings': ['Univ Florence, University of Florence, Dept Chem'], 'affiliations': [{'raw_affiliation_string': 'Univ Florence, University of Florence, Dept Chem', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110536710', 'display_name': 'Bernard Masereel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210152357', 'display_name': 'Pharmac', 'ror': 'https://ror.org/048macv48', 'country_code': 'NZ', 'type': 'government', 'lineage': ['https://openalex.org/I4210152357']}], 'countries': ['NZ'], 'is_corresponding': False, 'raw_author_name': 'Bernard Masereel', 'raw_affiliation_strings': ['Département de Pharmacie'], 'affiliations': [{'raw_affiliation_string': 'Département de Pharmacie', 'institution_ids': ['https://openalex.org/I4210152357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101539564', 'display_name': 'Ke‐He Ruan', 'orcid': 'https://orcid.org/0000-0001-7694-4452'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ke-He Ruan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087763748', 'display_name': 'Bernard Pirotte', 'orcid': 'https://orcid.org/0000-0001-8251-8257'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bernard Pirotte', 'raw_affiliation_strings': ['Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >'], 'affiliations': [{'raw_affiliation_string': 'Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >', 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5107998596', 'display_name': 'Philippe Kolh', 'orcid': 'https://orcid.org/0000-0001-5464-5515'}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Philippe Kolh', 'raw_affiliation_strings': ['Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. > > >'], 'affiliations': [{'raw_affiliation_string': 'Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. > > >', 'institution_ids': ['https://openalex.org/I157674565']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.25, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 77, 'citation_normalized_percentile': {'value': 0.810367, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '11', 'issue': '10', 'first_page': '1223', 'last_page': '1241'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9577, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9577, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thromboxane-a-synthase', 'display_name': 'Thromboxane-A synthase', 'score': 0.87594295}, {'id': 'https://openalex.org/keywords/thromboxane-receptor', 'display_name': 'Thromboxane receptor', 'score': 0.6858356}, {'id': 'https://openalex.org/keywords/prostaglandin-h2', 'display_name': 'Prostaglandin H2', 'score': 0.4128369}], 'concepts': [{'id': 'https://openalex.org/C173202427', 'wikidata': 'https://www.wikidata.org/wiki/Q408575', 'display_name': 'Thromboxane-A synthase', 'level': 4, 'score': 0.87594295}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.75499594}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.7143191}, {'id': 'https://openalex.org/C51603380', 'wikidata': 'https://www.wikidata.org/wiki/Q411978', 'display_name': 'Thromboxane receptor', 'level': 4, 'score': 0.6858356}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.67987275}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.62944144}, {'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.4233116}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42205888}, {'id': 'https://openalex.org/C2780978440', 'wikidata': 'https://www.wikidata.org/wiki/Q416567', 'display_name': 'Prostaglandin H2', 'level': 4, 'score': 0.4128369}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4097293}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.33969414}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24877149}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1993902}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16637808}], 'mesh': [{'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044262', 'descriptor_name': 'Prostaglandin H2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044262', 'descriptor_name': 'Prostaglandin H2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D044262', 'descriptor_name': 'Prostaglandin H2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044244', 'descriptor_name': 'Receptors, Thromboxane A2, Prostaglandin H2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D044244', 'descriptor_name': 'Receptors, Thromboxane A2, Prostaglandin H2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/0929867043365260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15134516', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2399782909', 'https://openalex.org/W2312229444', 'https://openalex.org/W2108301756', 'https://openalex.org/W2085760669', 'https://openalex.org/W2047854358', 'https://openalex.org/W2045421996', 'https://openalex.org/W2029344288', 'https://openalex.org/W1994245012', 'https://openalex.org/W1967177765', 'https://openalex.org/W106635558'], 'abstract_inverted_index': {'The': [0], 'pathogenesis': [1], 'of': [2, 19, 23, 36, 51, 61, 73, 131, 159, 165, 176], 'numerous': [3], 'cardiovascular,': [4], 'pulmonary,': [5], 'inflammatory,': [6], 'and': [7, 65, 84, 94, 118, 172], 'thromboembolic': [8, 85], 'diseases': [9], 'can': [10], 'be': [11], 'related': [12], 'to': [13], 'arachidonic': [14, 181], 'acid': [15], '(AA)': [16], 'metabolites.': [17], 'One': [18], 'these': [20], 'bioactive': [21], 'metabolites': [22], 'particular': [24], 'importance': [25], 'is': [26, 31, 57, 68], 'thromboxane': [27, 37, 91, 132, 163, 179, 183, 186, 189], 'A2': [28], '(TXA2).': [29], 'It': [30, 67], 'produced': [32], 'by': [33, 53, 102], 'the': [34, 40, 48, 54, 107, 116, 125, 129, 160], 'action': [35], 'synthase': [38, 92, 190], 'on': [39, 115], 'prostaglandin': [41], 'endoperoxide': [42], 'H2': [43], '(PGH2),': [44], 'which': [45, 134], 'results': [46], 'from': [47, 168], 'enzymatic': [49], 'degradation': [50], 'AA': [52], 'cyclooxygenases.': [55], 'TXA2': [56, 88], 'a': [58, 71, 157, 170, 173], 'potent': [59], 'inducer': [60], 'platelet': [62, 141], 'aggregation,': [63], 'vasoconstriction': [64], 'bronchoconstriction.': [66], 'involved': [69], 'in': [70], 'series': [72], 'major': [74, 166], 'pathophysiological': [75], 'states': [76], 'such': [77, 139], 'as': [78], 'asthma,': [79], 'myocardial': [80], 'ischemia,': [81], 'pulmonary': [82], 'hypertension,': [83], 'disorders.': [86], 'Therefore,': [87], 'receptor': [89, 187], 'antagonists,': [90], 'inhibitors': [93], 'drugs': [95], 'combining': [96], 'both': [97, 169], 'properties': [98], 'have': [99, 112], 'been': [100, 113], 'developed': [101], 'several': [103], 'pharmaceutical': [104], 'companies': [105], 'since': [106], 'early': [108], '1980s.': [109], 'Several': [110], 'compounds': [111], 'launched': [114], 'market': [117], 'others': [119], 'are': [120], 'under': [121], 'clinical': [122], 'evaluation.': [123], 'Moreover,': [124], 'recent': [126], 'literature': [127], 'reported': [128], 'interest': [130, 167], 'modulators,': [133], 'combine': [135], 'another': [136], 'pharmacological': [137, 171], 'activity': [138], 'as,': [140], 'activating': [142], 'factor': [143], 'antagonism,': [144, 147], 'angiotensin': [145], 'II': [146], 'or': [148], '5-lipoxygenase': [149], 'inhibition.': [150], 'In': [151], 'this': [152], 'review,': [153], 'we': [154], 'will': [155], 'propose': [156], 'description': [158], 'recently': [161], 'described': [162], 'modulators': [164], 'chemical': [174], 'point': [175], 'view.': [177], 'Keywords:': [178], 'a2,': [180], 'acid,': [182], 'synthase,': [184], 'prostanoids,': [185], 'antagonist,': [188], 'inhibitor': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2108301756', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-10T17:19:04.809779', 'created_date': '2016-06-24'}