Publication Information

{'id': 'https://openalex.org/W1541108101', 'doi': 'https://doi.org/10.1111/j.1432-1033.1978.tb12327.x', 'title': 'Biosynthesis of Thromboxane B<sub>2</sub> and 12‐<scp>l</scp>‐Hydroxy‐5,8,10‐heptadecatrienoic Acid in Human Platelets', 'display_name': 'Biosynthesis of Thromboxane B<sub>2</sub> and 12‐<scp>l</scp>‐Hydroxy‐5,8,10‐heptadecatrienoic Acid in Human Platelets', 'publication_year': 1978, 'publication_date': '1978-05-01', 'ids': {'openalex': 'https://openalex.org/W1541108101', 'doi': 'https://doi.org/10.1111/j.1432-1033.1978.tb12327.x', 'mag': '1541108101', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/658053'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1978.tb12327.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1978.tb12327.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1978.tb12327.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110128179', 'display_name': 'Amiram Raz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Amiram RAZ', 'raw_affiliation_strings': ['Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056943098', 'display_name': 'David Aharony', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'David AHARONY', 'raw_affiliation_strings': ['Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087370619', 'display_name': 'Rina Kenig-Wakshal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Rina KENIG‐WAKSHAL', 'raw_affiliation_strings': ['Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The George S. Wise Center for Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.796, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.800259, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '86', 'issue': '2', 'first_page': '447', 'last_page': '454'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thromboxane-a-synthase', 'display_name': 'Thromboxane-A synthase', 'score': 0.8707211}, {'id': 'https://openalex.org/keywords/prostaglandin-h2', 'display_name': 'Prostaglandin H2', 'score': 0.75651973}, {'id': 'https://openalex.org/keywords/thromboxane-b2', 'display_name': 'Thromboxane B2', 'score': 0.6297332}, {'id': 'https://openalex.org/keywords/thromboxane-receptor', 'display_name': 'Thromboxane receptor', 'score': 0.57615703}], 'concepts': [{'id': 'https://openalex.org/C173202427', 'wikidata': 'https://www.wikidata.org/wiki/Q408575', 'display_name': 'Thromboxane-A synthase', 'level': 4, 'score': 0.8707211}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.78930205}, {'id': 'https://openalex.org/C2780978440', 'wikidata': 'https://www.wikidata.org/wiki/Q416567', 'display_name': 'Prostaglandin H2', 'level': 4, 'score': 0.75651973}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.7558507}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.68840027}, {'id': 'https://openalex.org/C2781080829', 'wikidata': 'https://www.wikidata.org/wiki/Q3009646', 'display_name': 'Thromboxane B2', 'level': 3, 'score': 0.6297332}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.61967224}, {'id': 'https://openalex.org/C51603380', 'wikidata': 'https://www.wikidata.org/wiki/Q411978', 'display_name': 'Thromboxane receptor', 'level': 4, 'score': 0.57615703}, {'id': 'https://openalex.org/C2780664492', 'wikidata': 'https://www.wikidata.org/wiki/Q209717', 'display_name': 'Prostaglandin', 'level': 2, 'score': 0.5595524}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.48838967}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4690951}, {'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.4216195}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24373418}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18565059}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16677505}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12599567}], 'mesh': [{'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005231', 'descriptor_name': 'Fatty Acids, Unsaturated', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006880', 'descriptor_name': 'Hydroxy Acids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D013929', 'descriptor_name': 'Thromboxane B2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005231', 'descriptor_name': 'Fatty Acids, Unsaturated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006358', 'descriptor_name': 'Hot Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006880', 'descriptor_name': 'Hydroxy Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011463', 'descriptor_name': 'Prostaglandins H', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011463', 'descriptor_name': 'Prostaglandins H', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013929', 'descriptor_name': 'Thromboxane B2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013930', 'descriptor_name': 'Thromboxane-A Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1978.tb12327.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1978.tb12327.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/658053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1978.tb12327.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1978.tb12327.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.58}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1573463208', 'https://openalex.org/W1965418751', 'https://openalex.org/W1975989619', 'https://openalex.org/W1983759759', 'https://openalex.org/W1992106248', 'https://openalex.org/W2001850231', 'https://openalex.org/W2008738097', 'https://openalex.org/W2015850083', 'https://openalex.org/W2030087792', 'https://openalex.org/W2038443634', 'https://openalex.org/W2047206656', 'https://openalex.org/W2050568232', 'https://openalex.org/W2058994566', 'https://openalex.org/W2071112954', 'https://openalex.org/W2075397855', 'https://openalex.org/W2088333712', 'https://openalex.org/W2093101554', 'https://openalex.org/W2096552205', 'https://openalex.org/W2107569707', 'https://openalex.org/W2313917518'], 'related_works': ['https://openalex.org/W2437309711', 'https://openalex.org/W2408747893', 'https://openalex.org/W2399782909', 'https://openalex.org/W2396707059', 'https://openalex.org/W2252430178', 'https://openalex.org/W2072722254', 'https://openalex.org/W2047854358', 'https://openalex.org/W2045421996', 'https://openalex.org/W2029344288', 'https://openalex.org/W106635558'], 'abstract_inverted_index': {'Human': [0], 'platelet': [1], 'microsomes': [2], 'convert': [3], 'prostaglandin': [4, 84], 'H2': [5, 85, 118], 'to': [6, 24, 86, 121, 128], 'thromboxane': [7, 47, 65, 87, 98, 109, 130], 'B2': [8, 66, 110], 'and': [9, 34, 67, 89, 111], '12-L-hydroxy-5,8,10-heptadecatrienoic': [10], 'acid': [11], '(12OH-17:3)': [12], 'in': [13, 26, 58, 91], 'approximately': [14], 'equimolar': [15], 'amounts.': [16], 'The': [17, 94], 'synthesizing': [18], 'activities': [19, 29], 'of': [20, 46, 55, 83, 107], 'both': [21, 28, 64, 108], 'products': [22], 'appear': [23], 'go': [25], 'parallel,': [27], 'gradually': [30], 'decline': [31], 'upon': [32], 'storage': [33], 'are': [35, 69], 'equally': [36, 52], 'destroyed': [37], 'by': [38], 'heat': [39], 'inactivation.': [40], 'Furthermore': [41], 'imidazole,': [42], 'a': [43, 72], 'potent': [44], 'inhibitor': [45, 54], 'synthetase': [48], 'activity,': [49], 'is': [50, 119, 126], 'an': [51, 122], 'effective': [53], '12OH-17:3': [56, 90], 'formation': [57, 106], 'platelets.': [59, 93], 'These': [60], 'results': [61], 'suggest': [62], 'that': [63], '120H-17:3': [68], 'derived': [70], 'from': [71], 'common': [73, 102], 'intermediate.': [74], 'We': [75], 'propose': [76], 'two': [77], 'alternative': [78], 'pathways': [79], 'for': [80, 104], 'the': [81, 101, 105, 114], 'conversion': [82], 'A2': [88, 99, 131], 'human': [92], 'first': [95], 'pathway': [96], 'depicts': [97], 'as': [100], 'intermediate': [103, 124], '12OH-17:3.': [112, 133], 'In': [113], 'second': [115], 'pathway,': [116], 'prostaglanding': [117], 'converted': [120, 127], 'activated': [123], 'which': [125], 'either': [129], 'or': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1541108101', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-15T18:28:15.187483', 'created_date': '2016-06-24'}