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104, 110, 114, 117, 120, 126, 130], 'treatment': [12, 140], 'of': [13, 27, 48, 78, 107, 116, 119, 129], 'leukemias.': [14], 'Ara-C': [15], 'inhibits': [16], 'DNA': [17, 80, 142], 'polymerases': [18], 'and': [19, 35, 91, 98, 141], 'can': [20], 'be': [21], 'incorporated': [22, 55], 'into': [23], 'DNA.': [24], 'Its': [25], 'mechanism': [26, 176], 'cytotoxicity': [28], 'not': [30], 'fully': [31], 'understood.': [32], 'Using': [33], 'oligonucleotides': [34], 'purified': [36], 'human': [37, 149], 'topoisomerase': [38], 'I': [39], '(top1),': [40], 'we': [41, 153], 'found': [42], '4-': [44], 'to': [45, 63, 74, 87, 166], '6-fold': [46], 'enhancement': [47, 70], 'top1': [49, 66, 131, 145, 163, 171], 'cleavage': [50, 67, 146], 'complexes': [51, 147], 'when': [52], 'ara-C': [53, 83, 111, 139, 178], 'was': [54, 71], 'at': [56, 94, 99, 109], '+1': [58], 'position': [59], '(immediately': [60], '3′)': [61], 'relative': [62], 'unique': [65], 'site.': [68], 'This': [69, 134], 'primarily': [72], 'due': 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